Preparation of Cross-Linked Sodium Hyaluronate Gels with Different Molecular Weights of PEG and Research for its Viscoelasticity and Enzyme-Resistant Properties <i>In Vitro</i>
Abstract:Purpose To screen out the optimal conditions of cross-linking reaction of preparing for an injectable cross-linked sodium hyaluronate gel(CHA-gel) with higher resistance to hyaluronidase and research for its viscoelasticity and anti-enzyme degradation properties. Methods The CHA hydrogels were prepared with different molecular weights of PEG as cross-linking agent, such as PEG400, PEG1000, PEG6000, PEG10000, PEG20000. The optimal preparing conditions were determined by single factor test and orthogonal experim… Show more
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