Preparation of core-shell microcapsules based on microfluidic technology for the encapsulation, protection and controlled delivery of phycocyanin

Revolutionizing targeting precision: microfluidics-enabled smart microcapsules for tailored delivery and controlled release

“…The most preponderant mechanism; the concentration gradient as the driving force; the pore size is large enough to allow the encapsulants to transport Dissolution/melting Membrane-based disintegration, easy to design; starting from outside the carriers and progressing to the inside Disintegration Membrane-based disintegration, cleavage of cross-links, triggered depolymerization, mechanical-induced degradation Swelling/shrink Membrane-based permeability alteration even breaks the shell and solvent absorption Osmosis Membrane-based permeability alteration even breaks the shell, selectively water-permeable of the carrier delivery has been produced through shell degradation, in which around 20% of the protein was released in the stomach and small intestinal fluid and about 58% was released in the colon fluid containing β-glucosidase. 110 Additionally, carriers with depolymerizable membranes offer tunable trigger release by depolymerizing the shell under the desired stimuli.…”

“…By introducing hydrogen bonds between molecules to construct the stable shell, a high encapsulation efficiency of up to 98% was achieved, and the stability and bioavailability of phycocyanin were improved. 110 The dense shell thickness is an important parameter for mechanical properties and can be adjusted by microfluidics precursor concentration, flow rate, and viscosity. Homogeneous shell thickness is conducive to maintaining mechanical stability but requires higher osmotic pressure for encapsulant release, which may not be suitable for certain biomedical applications.…”

Piggery Wastewater Treatment Using Photosynthetic Microorganisms

“…In addition, cyanobacteria can synthesize pigments belonging to the group of phycobiliproteins. An important and rare pigment of this last group is phycocyanin, a pigment with a striking blue colour that can absorb at wavelengths of ~620 nm and present promising antibacterial, anticancer, anti-inflammatory and antioxidant activities [12,94]. All those pigments are nowadays commercialized for the production of cosmetics, pharmaceuticals and functional foods.…”

A review of recent strategies to improve the physical stability of phycocyanin

“…Encapsulation technologies can be used to protect sensitive bioactive molecules by packaging them within particles with micrometer- or nanometer-scale dimensions ( Tie et al, 2022 ; Wang et al, 2022 ; Yu et al, 2022 ).…”