Preparation of complex microcapsules of soluble polysaccharide from Glycyrrhiza uralensis and its application in wound repair and scar inhibition

Hao, Baocheng; Wang, Xinjian; Ma, Xueqing; Jin, Yongming; Fan, Wei; Laba, Cidan; Wujin, Cuomu; Wang, Yonggang; Liang, Jianping

doi:10.1016/j.ijbiomac.2020.03.121

Cited by 24 publications

(20 citation statements)

References 44 publications

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“…showed that licorice from Inner Mongolia exhibited higher contents of LQ, GA, and five total compounds, which was consistent with the fact that licorice from Inner Mongolia was the mainstream of market (Hao et al, 2020). Meanwhile, some scholars adopted both Japanese Pharmacopoeia and Chinese Pharmacopoeia as double standards to detect the licorice collected from the eastern, southern, and western parts of Mongolia, and pointed out that the producing area indeed greatly affected the quality of licorice, which should be considered to ensure high quality of licorice used in prescription (Zhu et al, 2009).…”

Section: Pcasupporting

confidence: 82%

Chemometric analysis of active compounds and antioxidant and α‐glucosidase inhibitory activities for the quality evaluation of licorice from different origins

Xue-mei

Guo

Zhao

et al. 2021

Biomedical Chromatography

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Contents of total flavonoids (TFc), total phenolics (TPc), and total crude polysaccharide (TCPc) in licorice from different origins were determined by optimized colorimetric methods, whereas five monomer ingredients (liquiritin [LQ], isoliquiritin [ILQ], liquiritigenin [LQG], isoliquiritigenin [ILQG], and glycyrrhizic acid [GA]) were simultaneously identified and quantified by HPLC-MS and HPLC. The results indicated that the contents of chemical compounds in licorice showed significant difference in different origins. Hierarchical cluster analysis and principal component analysis further proved that producing area indeed affected the quality including compounds and pharmacological activity in licorice. Licorice from Inner Mongolia exhibited the excellent DPPH assay, whereas samples from Gansu and Xinjiang showed high scavenging capacity to OH and ABTS free radicals. Meanwhile, α-Glu inhibitory activity of licorice samples was four times higher than the antioxidant activity. Correlation analysis made clear that TFc and TCPc both strongly contribute to DPPH scavenge capacity at P < 0.01 level, whereas TCPc contributed to α-Glu inhibitory activity at P < 0.05 level. This study would contribute to the comprehensive quality evaluation based on the compounds and pharmacological activity of licorice, and provide a reference for the choice of producing area to ensure the quality of licorice as a medicine.

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Section: Pcasupporting

confidence: 82%

Chemometric analysis of active compounds and antioxidant and α‐glucosidase inhibitory activities for the quality evaluation of licorice from different origins

Xue-mei

Guo

Zhao

et al. 2021

Biomedical Chromatography

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“…Among them, Glycyrrhiza polysaccharides ( GPS ) as functional compounds have attracted more and more researchers in both pharmaceutical and alimentary field ( Chu et al., 2012 ). GPS are consist of different types of monosaccharides like glucose, galactose, and mannose ( Pan et al., 2020 ), and have various medicinal uses such as antitumor agent, antibacterial, antiviral, antioxidant, and protective agent to the liver and kidney ( Ayeka et al., 2016 ; Wu et al., 2017 ; Lian et al., 2018 ; Zhang et al., 2018 ; Hao et al., 2020 ; Mutaillifu et al., 2020 ; Pan et al., 2020 ). GPS can boost immune function, stimulate the antigen presenting cells like macrophages and dendritic cells, as well as help secrete cytokines and induce immune cells to mature.…”

Section: Introductionmentioning

confidence: 99%

Glycyrrhiza polysaccharides can improve and prolong the response of chickens to the Newcastle disease vaccine

Zhang

et al. 2022

Poultry Science

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Licorice is a medicinal and food plant widely used to treat diseases and produce food additives, because of its unique chemical constituents like polysaccharides, flavones, and saponins. Glycyrrhiza Polysaccharides ( GPS-1 ) are water-soluble neutral polysaccharides extracted from licorice. Currently, GPS-1 is administrated to chickens by gavage every d for 14 d to observe the impact of GPS-1 on the Newcastle disease vaccine. To determine the immunity of these chickens to NDV, blood serum levels of hemagglutinin-inhibition ( HI ) antibody, and immunoglobulins IgA and IgG were measured. Meanwhile, the expression levels of cytokines IL-2, IL-4, IL-17, and IFN-γ were measured to evaluate the degree of immune booster activity. The chickens’ spleen and peripheral blood lymphocytes displayed a significant increase in the proportion of CD4+ and CD8+ T cells after booster treatments with GPS-1. The results indicated that GPS-1 had a significant, dose-dependent, immune-boosting effect which could enhance NDV vaccine immunity in chickens.

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“…Other than small molecules, macromolecules such as polysaccharide may also be the active components of WG. Many studies have reported the biological activities of licorice polysaccharide [78][79][80]. Further study is needed to fully understand the active components in WG that synergistically act on chondrocyte hypertrophy related OA.…”

Section: Discussionmentioning

confidence: 99%

In Vitro Study of Licorice on IL-1β-Induced Chondrocytes and In Silico Approach for Osteoarthritis

Ali¹,

Park²,

Lee

et al. 2021

Pharmaceuticals

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Osteoarthritis (OA) is a common degenerative joint disorder that affects joint function, mobility, and pain. The release of proinflammatory cytokines stimulates matrix metalloproteinases (MMPs) and aggrecanase production which further induces articular cartilage degradation. Hypertrophy-like changes in chondrocytes are considered to be an important feature of OA pathogenesis. A Glycyrrhiza new variety, Wongam (WG), was developed by the Korea Rural Development Administration to enhance the cultivation and quality of Glycyrrhizae Radix et Rhizoma (licorice). This study examined the regulatory effect of WG against hypertrophy-like changes such as RUNX2, Collagen X, VEGFA, MMP-13 induction, and Collagen II reduction induced by IL-1β in SW1353 human chondrocytes. Additionally, in silico methods were performed to identify active compounds in licorice to target chondrocyte hypertrophy-related proteins. WG showed inhibitory effects against IL-1β-induced chondrocyte hypertrophy by regulating both HDAC4 activation via the PTH1R/PKA/PP2A pathway and the SOX9/β-catenin signaling pathway. In silico analysis demonstrated that 21 active compounds from licorice have binding potential with 11 targets related to chondrocyte hypertrophy. Further molecular docking analysis and in vivo studies elicited four compounds. Based on HPLC, isoliquiritigenin and its precursors were identified and quantified. Taken together, WG is a potential therapeutic agent for chondrocyte hypertrophy-like changes in OA.

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Preparation of complex microcapsules of soluble polysaccharide from Glycyrrhiza uralensis and its application in wound repair and scar inhibition

Cited by 24 publications

References 44 publications

Chemometric analysis of active compounds and antioxidant and α‐glucosidase inhibitory activities for the quality evaluation of licorice from different origins

Chemometric analysis of active compounds and antioxidant and α‐glucosidase inhibitory activities for the quality evaluation of licorice from different origins

Glycyrrhiza polysaccharides can improve and prolong the response of chickens to the Newcastle disease vaccine

In Vitro Study of Licorice on IL-1β-Induced Chondrocytes and In Silico Approach for Osteoarthritis

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