Preparation of Cis- and Trans 2,5-Dimethoxy-2-(acetamidomethyl)-2,5-dihydrofuran, of Cis- and Trans 2,5-Dimethoxy-2-(acetamidomethyl)-tetrahydrofuran and of 1-Phenyl-2-(acetamidomethyl)-pyrrole.

Arylsulfone-Based HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors

“…Pyrrylarylsulfones were synthesized by arylsulfonation of pyrroles in the presence of potassium tert-butoxide and 18-crown-6 in tetrahydrofuran or via Clauson-Kaas reaction by heating with 2,5-dimethoxytetrahydrofuran in boiling glacial acetic acid [38]. Alkyl 1-(2-nitrophenylsulfonyl)-1H-pyrrole-2-carboxylate were reduced to amino with iron powder in glacial acetic acid (SupplementaRy FiguRe 2).…”

Novel Design of Nonpeptide AVP V2Receptor Agonists: Structural Requirements for an Agonist Having 1-(4-Aminobenzoyl)-2,3,4,5-tetrahydro-1H-1-benzazepine as a Template

“…The resulting precipitates were crystallized with Et2O to give 10 (44.6 g, 93%) as a white powder: 1 H NMR (200 MHz, CDCl3) δ 1.43-1.91 (4H, m), 2.22-2.47 (2H, m), 2.42 (3H, s), 3.41-3.93 (2H, m), 7.05-7.35 (5H, m), 7.52-7.67 (2H, m). 7-Chloro-1,2,3,4-tetrahydro-1H-1-benzazepine (11). To a solution of tosylate 10 (30 g, mmol) in MeOH (300 mL) was slowly added Mg (7.2 g, mmol) to maintain a gentle reflux and H2 evolution.…”

A magenta polypyrrole derivatised with Methyl Red azo dye: synthesis and spectroelectrochemical characterisation

“…The synthetic route to obtain MRPy was divided into two steps: i) the preparation of the 1-(3-iodopropyl)pyrrole according to the procedure described by Clauson-Kaas and Tyle [25][26][27], and ii) the esterification step by the nucleophilic substitution reaction of 1-(3-iodopropyl)pyrrole and MR, in the presence of triethylamine/ CH 3 CN (Scheme 1). This method has the advantages of simplicity, mild conditions and good yields from readily available starting materials.…”