Preparation of cinnamaldehyde nanoemulsions: Formula optimization, antifungal activity, leaf adhesion, and safety assessment

Feng, Jianguo; Sun, Li; Zhai, Tianyun; Liang, Qianwei; Jiang, Tianzhen; Chen, Ziyang

doi:10.1016/j.indcrop.2023.116825

Cited by 9 publications

(2 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As indicated in Figure 3 a, when the solid content is kept at a fixed level, the Z-average particle size decreases and then increases as the weight ratio of HEMA-3 and Avm (A) increased, with a minimum value in the range from 52.36% to 71.41%, due to the fact that a suitable concentration of HEMA-3 is required for the formation of nanoemulsions. At a lower concentration of HEMA-3, the nanoemulsion does not form a complete stabilizing surface layer, resulting in agglomeration [ 48 , 49 ]. While at a higher concentration of HEMA-3, the bridging of the emulsifier molecules or the formation of empty micelles can lead to flocculation or the Ostwald ripening [ 50 ].…”

Section: Resultsmentioning

confidence: 99%

Fabrication of Eco-Friendly Hydrolyzed Ethylene–Maleic Anhydride Copolymer–Avermectin Nanoemulsion with High Stability, Adhesion Property, pH, and Temperature-Responsive Releasing Behaviors

Cheng,

Pan,

Tang

et al. 2024

Molecules

View full text Add to dashboard Cite

In this study, novel amphiphilic polymer emulsifiers for avermectin (Avm) were synthesized facilely via the hydrolysis of ethylene-maleic anhydride copolymer (EMA) with different agents, and their structures were confirmed by various techniques. Then, water-based Avm-nanoemulsions were fabricated with the emulsifiers via phase inversion emulsification process, and superior emulsifier was selected via the emulsification effects. Using the superior emulsifier, an optimal Avm-nanoemulsion (defined as Avm@HEMA) with satisfying particle size of 156.8 ± 4.9 nm, encapsulation efficiency (EE) of 69.72 ± 4.01% and drug loading capacity (DLC) of 54.93 ± 1.12% was constructed based on response surface methodology (RSM). Owing to the emulsifier, the Avm@HEMA showed a series of advantages, including high stability, ultraviolet resistance, low surface tension, good spreading and high affinity to different leaves. Additionally, compared to pure Avm and Avm-emulsifiable concentrate (Avm-EC), Avm@HEMA displayed a controlled releasing feature. The encapsulated Avm was released quite slowly at normal conditions (pH 7.0, 25 °C or 15 °C) but could be released at an accelerated rate in weak acid (pH 5.5) or weak alkali (pH 8.5) media or at high temperature (40 °C). The drug releasing profiles of Avm@HEMA fit the Korsmeyer–Peppas model quite well at pH 7.0 and 25 °C (controlled by Fickian diffusion) and at pH 7.0 and 10 °C (controlled by non-Fickian diffusion), while it fits the logistic model under other conditions (pH 5.5 and 25 °C, pH 8.5 and 25 °C, pH 7.0 and 40 °C).

show abstract

Section: Resultsmentioning

confidence: 99%

Fabrication of Eco-Friendly Hydrolyzed Ethylene–Maleic Anhydride Copolymer–Avermectin Nanoemulsion with High Stability, Adhesion Property, pH, and Temperature-Responsive Releasing Behaviors

Cheng,

Pan,

Tang

et al. 2024

Molecules

View full text Add to dashboard Cite

show abstract

“…[2] With advancements in science and technology and increasing awareness of ecological protection, the pursuit of new, highly efficient, low-toxicity, and environmentally friendly natural substances to replace chemically synthesized fungicides has became a prominent research topic. [3] Plantderived fungicides refer to a class of pesticides obtained by extracting active ingredients from plants with bactericidal and bacteriostatic activity, [4] which were mainly distributed in different parts of the plant such as roots, stems, leaves, flowers, fruits, seeds, [5] and isolating and purifying them for processing. These active compounds were then isolated and purified for further processing, resulting in plant-derived fungicides that were effective in preventing and controlling fungal infections in plants.…”

Section: Introductionmentioning

confidence: 99%

Industrial Distillation Fractions of Garlic Essential Oil, Design, Synthesis, and Antifungal Activity Evaluation of Aliphatic Substituted Trisulfide Derivatives

Chen,

Wang,

Wang

et al. 2024

Chemistry & Biodiversity

View full text Add to dashboard Cite

Garlic oil has a wide range of biological activities, and its broad‐spectrum activity against phytopathogenic fungi still has the potential to be explored. In this study, enzymatic treatment of garlic resulted in an increase of approximately 50 % in the yield of essential oil, a feasible GC‐MS analytical program for garlic oil was provided. Vacuum fractionation of the volatile oil and determination of its inhibitory activity against 10 fungi demonstrated that garlic oil has good antifungal activity. The antifungal activity levels were ranked as diallyl trisulfide (S‐3)>diallyl disulfide (S‐2)>diallyl monosulfide (S‐1), with an EC50 value of S‐3 against Botrytis cinerea reached 8.16 mg/L. Following the structural modification of compound S‐3, a series of derivatives, including compounds S‐4~7, were synthesized and screened for their antifungal activity. The findings unequivocally demonstrated that the compound dimethyl trisulfide (S‐4) exhibited exceptional antifungal activity. The EC50 of S‐4 against Sclerotinia sclerotiorum reached 6.83 mg/L. SEM, In vivo experiments, and changes in mycelial nucleic acids, soluble proteins and soluble sugar leakage further confirmed its antifungal activity. The study indicated that the trisulfide bond structure was the key to good antifungal activity, which can be developed into a new type of green plant‐derived fungicide for plant protection.

show abstract

Optimization of multifunctional polymer emulsifiers properties for lambda-cyhalothrin nanoemulsion fabrication

Cheng,

Guan,

Tang

et al. 2024

Colloids and Surfaces A: Physicochemical and Engineering Aspect

View full text Add to dashboard Cite

Preparation of cinnamaldehyde nanoemulsions: Formula optimization, antifungal activity, leaf adhesion, and safety assessment

Cited by 9 publications

References 59 publications

Fabrication of Eco-Friendly Hydrolyzed Ethylene–Maleic Anhydride Copolymer–Avermectin Nanoemulsion with High Stability, Adhesion Property, pH, and Temperature-Responsive Releasing Behaviors

Fabrication of Eco-Friendly Hydrolyzed Ethylene–Maleic Anhydride Copolymer–Avermectin Nanoemulsion with High Stability, Adhesion Property, pH, and Temperature-Responsive Releasing Behaviors

Industrial Distillation Fractions of Garlic Essential Oil, Design, Synthesis, and Antifungal Activity Evaluation of Aliphatic Substituted Trisulfide Derivatives

Optimization of multifunctional polymer emulsifiers properties for lambda-cyhalothrin nanoemulsion fabrication

Contact Info

Product

Resources

About