Preparation of Chitosan Nanoparticles Loaded with Vascular Endothelial Growth Factor and Its Application in the Treatment of Skin Injury
Hongmei Tang,
Zhe Deng,
Tianlan Zhao
Abstract:This research was aimed to explore the application of chitosan (CS) nanoparticles (NPs) loaded with vascular endothelial growth factor (VEGF) in rat skin injury. Method: the VEGF-loaded CS NPs (VEGF/CS-NPs) were prepared, and a skin injury model on the back skin of rats was established.
The VEGF/CS-NPs were applied to the injury model to observe the skin changes in the wound area of each group, compare the healing rate, the number of micro-vessels, and VEGF expression in each group of rats, so as to explore t… Show more
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