Preparation of cellulose-based fluorescent materials using Zinc sulphide quantum dot-decorated graphene by a one-step hydrothermal method

Bian, Yanqin; He, Beihai; Li, Junrong

doi:10.1007/s10570-016-0988-9

Cited by 15 publications

(5 citation statements)

References 24 publications

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“…GOx is first obtained following the improved Hummers’ method and was further dispersed in HPDW. GOx is then decorated with ZnS:Mn QDs following a well-studied hydrothermal-assisted co-precipitation method used in similar graphene/QDs systems [ 46 , 47 , 48 ]. The surface morphology, particle size and particle abundance of the so-synthesized nanocomposite are depicted in Figure 1 .…”

Section: Resultsmentioning

confidence: 99%

Graphene Oxide/ZnS:Mn Nanocomposite Functionalized with Folic Acid as a Nontoxic and Effective Theranostic Platform for Breast Cancer Treatment

et al. 2018

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Nanoparticle-based cancer theranostic agents generally suffer of poor dispersability in biological media, re-agglomeration over time, and toxicity concerns. To address these challenges, we developed a nanocomposite consisting of chemically-reduced graphene oxide combined with manganese-doped zinc sulfide quantum dots and functionalized with folic acid (FA-rGO/ZnS:Mn). We studied the dispersion stability, Doxorubicin (DOX) loading and release efficiency, target specificity, internalization, and biocompatibility of FA-rGO/ZnS:Mn against folate-rich breast cancer cells, and compared to its uncoated counterpart (rGO/ZnS:Mn). The results indicate that DOX is adsorbed on the graphene surface via π–π stacking and hydrophobic interaction, with enhanced loading (~35%) and entrapment (~60%) efficiency that are associated to the chelation of DOX and surface Zn2+ ions. DOX release is favored under acidic conditions reaching a release of up to 95% after 70 h. Membrane integrity of the cells assessed by Lactate dehydrogenase (LDH) release indicate that the surface passivation caused by folic acid (FA) functionalization decreases the strong hydrophobic interaction between the cell membrane wall and the edges/corners of graphene flakes. Chemotherapeutic effect assays reveal that the cancer cell viability was reduced up to ~50% at 3 µg/mL of DOX-FA-rGO/ZnS:Mn exposure, which is more pronounced than those obtained for free DOX at the same doses. Moreover, DOX-rGO/ZnS:Mn did not show any signs of toxicity. An opposite trend was observed for cells that do not overexpress the folate receptors, indicating that FA functionalization endows rGO/ZnS:Mn with an effective ability to discriminate positive folate receptor cancerous cells, enhancing its drug loading/release efficiency as a compact drug delivery system (DDS). This study paves the way for the potential use of functionalized rGO/ZnS:Mn nanocomposite as a platform for targeted cancer treatment.

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Section: Resultsmentioning

confidence: 99%

Graphene Oxide/ZnS:Mn Nanocomposite Functionalized with Folic Acid as a Nontoxic and Effective Theranostic Platform for Breast Cancer Treatment

et al. 2018

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“…A one‐step hydrothermal method developed by Bian and co‐workers allows the production of cellulose‐based fluorescence materials by loading ZnS quantum‐dot‐decorated graphene directly onto the surface of paper fibers (Figure ). The composite exhibits only a fewer defects and high fluorescence intensity.…”

Section: Membrane‐based Fluorescent Cellulosementioning

confidence: 99%

Fluorescence Sensing with Cellulose‐Based Materials

Xiao

et al. 2017

ChemistryOpen

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Cellulose‐based materials functionalized with fluorescence sensors are highly topical and are employed in many areas of functional materials, including the sensing of heavy‐metal ions and anions as well as being widely used as chemical sensors and tools for environmental applications. In this Review, we cover recent progress in the development of cellulose‐based fluorescence sensors as parts of membranes and nanoscale materials for the detection of biological analytes. We believe that this Review will be of interest to chemists, chemical engineers, and biochemists in the sensor community as well as researchers working with biological material systems.

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“… 22 These ZnS QDs were immobilized onto the graphene surface using hydrothermal co-precipitation, exhibiting the strong fluorescence. 23 As ZnS(Mn) exhibits phosphorescence emission (~590 nm), the interference from biological tissues can be avoided as phosphorescence, making it an ideal candidate for biomedical applications. 24 , 25 , However, most of the QDs were immobilized on the graphene surface via hydrothermal assisted co-precipitation above 150 ° C resulting reduced graphene oxide (rGO), which is less favored over GO for biomedical applications due to higher water dispersibility and biocompatibility of GO.…”

Section: Introductionmentioning

confidence: 99%

Biodegradable Nanocomposite of ZnS(Mn) Quantum Dots Immobilized Graphene Oxide for Bioimaging Applications

Kurungottu,

Thomas,

Lalitha

et al. 2024

Nanotheranostics

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Developing a biocompatible and biodegradable graphene-based fluorescent nanoprobe with the ability to visualize live cells could be interesting for intracellular imaging and monitoring the efficiency of chemotherapy. Herein, we report a biodegradable and biocompatible hybrid fluorescent graphene oxide (GO)-ZnS(Mn) composite synthesized via in situ growth of ZnS(Mn) quantum dots (QDs) on the surface of GO in the aqueous medium. The prepared 'GO-ZnS(Mn)' composite was characterized by X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), thermogravimetric analysis (TGA) and high-resolution transmission electron microscopy (HR-TEM) along with selected area electron diffraction (SAED). Further, the fluorescence properties of the GO-ZnS(Mn) composite were studied using fluorescence emission spectroscopy. The composite material exhibited a strong and broad visible light fluorescence from 500 to 600 nm by excitation with 365 nm (UV) light. The cytotoxic experiments of folic acid (FA) conjugated GO-ZnS(Mn) using MTT [(3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide)] assay revealed that the composite had excellent biocompatibility even at higher concentrations up to 200 µg/mL in HeLa cell lines. Next, the bioimaging experiments carried out using confocal fluorescence laser scanning microscopy (CLSM) revealed that GO-ZnS(Mn) composite was taken up by the HeLa cells effectively within 12 h of incubation via receptor (folate) mediated endocytosis with strong fluorescence throughout the cell surface. Finally, the biodegradability of GO-ZnS(Mn) composite was studied by treating it with human myeloperoxidase enzyme (hMPO) isolated from the primary immune cells, neutrophils, which is important to understand the in vivo fate of GO-Zns(Mn). The HR-TEM and Raman analyses confirmed the biodegradation of GO-ZnS(Mn) within 15 h of hMPO treatment. Thus, the biodegradable GO-ZnS (Mn) composite could be helpful for chemotherapy and bioimaging applications.

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Preparation of cellulose-based fluorescent materials using Zinc sulphide quantum dot-decorated graphene by a one-step hydrothermal method

Cited by 15 publications

References 24 publications

Graphene Oxide/ZnS:Mn Nanocomposite Functionalized with Folic Acid as a Nontoxic and Effective Theranostic Platform for Breast Cancer Treatment

Graphene Oxide/ZnS:Mn Nanocomposite Functionalized with Folic Acid as a Nontoxic and Effective Theranostic Platform for Breast Cancer Treatment

Fluorescence Sensing with Cellulose‐Based Materials

Biodegradable Nanocomposite of ZnS(Mn) Quantum Dots Immobilized Graphene Oxide for Bioimaging Applications

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