Preparation of cellulose acetate butyrate and poly(ethylene glycol) copolymer to blend with poly(3‐hydroxybutyrate)

Cheng, Guoxiang; Wang, Tiezhu; Zhao, Qiang; Ma, Xiaolu; Zhang, Liguang

doi:10.1002/app.23135

Cited by 14 publications

(13 citation statements)

References 13 publications

(8 reference statements)

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“…Moreover, by varying parameters such as the degree of polymerization, polydispersities of the main chain and the side chains, gra density, and the distribution of the gras, a more polymeric material with more valuable properties may result. 217 Graing of cellulose acetate with other polymers such as poly(lactic acid), 232,233 poly(methyl methacrylate), 231,234 poly(hydroxybutyrate-co-valerate), 235 caprolactone, 32 polystyrene, 236 poly(ethylene glycol) and poly-(hydroxybutyrate) 237 with new and improved performance features including better conductivity, thermal stability, and other marked advantages with better control and property tuning capability has been reported in the literature.…”

Section: Cellulose Acetatementioning

confidence: 99%

Progress in bio-based plastics and plasticizing modifications

Mekonnen

Mussone

Khalil³

et al. 2013

J. Mater. Chem. A

665

423

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Over the coming few decades bioplastic materials are expected to complement and gradually replace some of the fossil oil based materials. Multidisciplinary research efforts have generated a significant level of technical and commercial success towards these bio-based materials. However, extensive application of these bio-based plastics is still challenged by one or more of their possible inherent limitations, such as poor processability, brittleness, hydrophilicity, poor moisture and gas barrier, inferior compatibility, poor electrical, thermal and physical properties. The incorporation of additives such as plasticizers into the biopolymers is a common practice to improve these inherent limitations. Generally, plasticizers are added to both synthetic and bio-based polymeric materials to impart flexibility, improve toughness, and lower the glass transition temperature. This review introduces the most common bio-based plastics and provides an overview of recent advances in the selection and use of plasticizers, and their effect on the performance of these materials. In addition to plasticizers, we also present a perspective of other emerging techniques of improving the overall performance of bio-based plastics. Although a wide variety of bio-based plastics are under development, this review focuses on plasticizers utilized for the most extensively studied bioplastics including poly(lactic acid), polyhydroxyalkanoates, thermoplastic starch, proteinaceous plastics and cellulose acetates. The ongoing challenge and future potentials of plasticizers for bio-based plastics are also discussed.

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Section: Cellulose Acetatementioning

confidence: 99%

Progress in bio-based plastics and plasticizing modifications

Mekonnen

Mussone

Khalil³

et al. 2013

J. Mater. Chem. A

665

423

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“…The advantage of CMC is film formulation and the ability to blend with other polymers such as poly(ethylene glycol) (PEG), which is biocompatible, less toxic, and hydrophilic. 34 …”

Section: Introductionmentioning

confidence: 99%

Characterization and Evaluation of Carboxymethyl Cellulose-Based Films for Healing of Full-Thickness Wounds in Normal and Diabetic Rats

Basu¹,

Narendrakumar²,

Arunachalam

et al. 2018

ACS Omega

102

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Artificial skin substitute made of polymeric films are of great demand in the field of skin tissue engineering. We report here the fabrication of carboxymethyl cellulose (CMC) and poly(ethylene glycol) (PEG) blend films by solution casting method for wound healing applications. The physicochemical characteristics and the thermal stability of the films were analyzed. The surface morphology shows crystalline structures with large hexagonal-like platelet crystals of CMC on the surface of the films. Pure CMC films exhibited higher tensile strength than the CMC/PEG blend films. The swelling ratio (SR) of the films was influenced by the pH of Tris–HCL buffer (2.0, 5.0, and 7.0), which increased with increase in pH. The hemocompatibility assay and cytotoxicity test using NIH 3T3 fibroblast cells showed that the films were biocompatible. To evaluate the wound healing efficacy, the films were applied in full-thickness wounds created in normal and diabetic Wistar albino rats. The wounds healed faster with pure CMC film compared to blend films in both normal and diabetic rats, evidenced by intensive collagen formation in histopathological analysis. Thus, the films have potential application in skin regeneration, thereby to restore the structural and functional characteristics of the skin.

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“…PEG (Figure 1(b)) is an ideal candidate for blending with PHB, a flexible polymer with good solubility in both water and organic solvents; it is used in protein purification processes, as well as a drug carrier and various other pharmaceutical applications [10,11]. A range of PEGs can be synthesised with average molecular weights (Mn) from 106 (diethylene glycol, DEG) to 20,000.…”

Section: Introductionmentioning

confidence: 99%

“…Blending PHB with polyethylene glycol (PEG) reduces crystallinity and other physiochemical properties of the composite biomaterial [11,14]. Tan et al reported that PEG polymer chains remained mobile when PHB underwent crystallisation and moved to intra-and interspherulitic regions [15].…”

Section: Introductionmentioning

confidence: 99%

Application of Polyethylene Glycol to Promote Cellular Biocompatibility of Polyhydroxybutyrate Films

Chan¹,

Marçal²,

Russell³

et al. 2011

International Journal of Polymer Science

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Polyhydroxybutyrate (PHB) is a biomaterial with potential for applications in biomedical and tissue engineering; however, its brittle nature and high crystallinity limit its potential. Blending PHB with a variety of PEGs produced natural-synthetic composite films composed of FDA-approved polymers with significant reductions in crystallinity, from 70.1% for PHB films to 41.5% for its composite with a 30% (w/w) loading of PEG2000. Blending also enabled manipulation of the material properties, increasing film flexibility with an extension to break of2.49±1.01%for PHB films and8.32±1.06%for films containing 30% (w/w) PEG106. Significant changes in the film surface properties, as measured by porosity, contact angles, and water uptake, were also determined as a consequence of the blending process, and these supported greater adhesion and proliferation of neural-associated olfactory ensheathing cells (OECs). A growth rate of7.2×105cells per day for PHB films with 30% (w/w) PEG2000 loading compared to2.5×105for PHB films was observed. Furthermore, while cytotoxicity of the films as measured by lactate dehydrogenase release was unaffected, biocompatibility, as measured by mitochondrial activity, was found to increase. It is anticipated that fine control of PEG composition in PHB-based composite biomaterials can be utilised to support their applications in medicinal and tissue engineering applications.

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Preparation of cellulose acetate butyrate and poly(ethylene glycol) copolymer to blend with poly(3‐hydroxybutyrate)

Cited by 14 publications

References 13 publications

Progress in bio-based plastics and plasticizing modifications

Progress in bio-based plastics and plasticizing modifications

Characterization and Evaluation of Carboxymethyl Cellulose-Based Films for Healing of Full-Thickness Wounds in Normal and Diabetic Rats

Application of Polyethylene Glycol to Promote Cellular Biocompatibility of Polyhydroxybutyrate Films

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