Preparation of carboxylic arylphosphines by hydrolysis of the trifluoromethyl group

Abstract

Preparation of carboxylic triarylphosphines by hydrolysis of the trifluoromethyl group in acid media.

Unlocking flavin photoacid catalysis through electrophotochemistry

“…Triuoromethylarenes are hydrolyzed under strongly acidic conditions, producing benzoic acids. [55][56][57][58][59][60][61][62][63] SET, HAT, or PCET mechanisms lead to S N Ar of the methoxy- [64][65][66] or triuoromethyl-group, 67 electrophilic aromatic substitution, 68 or a-functionalization of the aryl ether, 69-71 Fig. 2.…”

Fluorinated triphenylphosphonium analogs improve cell selectivity and in vivo detection of mito-metformin

“…A mixture of 0.500 g (1.37 mmol) of N -(10-bromodecyl)phthalimide in DMF (12.6 mL) was heated with tris(3-trifluoromethyl)phosphine 45 (0.637 g, 1.37 mmol) for 51 h. Flash chromatography gave 0.442 g (76%) of the title compound.…”