Preparation of BSA-coated Au Nanoparticles Contrast Agent and Its Application in PETCT Imaging

Abstract

Tumors are the biggest opponents in the history of human diseases, and they cannot be eliminated so far. The only way to treat tumors is to detect them early so that the survival rate can be improved by early treatment. For tumor detection, CT scan is the most commonly used, and PET/CT is an enhanced version of CT technology. Although PET/CT can produce relatively clear images of the human body, due to the complex structure of the human body, there are many ghosts and shadows, and the images cannot be accurately judged. Therefore, this paper aims to prepare high-definition nanoparticle contrast agents, hoping to make PET/CT images clearer and easier to distinguish. In this paper, the advantages of gold nanoparticles are fully analyzed for the preparation of contrast agents, and a gold nano-contrast agent coated with bovine serum albumin (BSA) is proposed. Gold nanoparticles (GNRs) were prepared by the traditional induction method and their properties were analyzed. Finally, taking mice as the experimental object, a comparative experiment was carried out, and the toxicological and optical properties were analyzed. The experimental results show that the adsorption performance of the BSAcoated gold nanoparticles prepared in this paper is more than 90% at different temperatures. And through the comparison experiment, the contrast agent prepared in this paper has an increased signal-tonoise(StN) ratio change rate of more than 50%, which can be well applied to PET/CT imaging.

Albumin-Modified Gold Nanoparticles as Novel Radiosensitizers for Enhancing Lung Cancer Radiotherapy

“…[40][41][42] Owing to the emission of low-energy photoelectrons and the interaction of Auger electrons, high-Z nanomaterials can absorb, scatter, and eradicate radiation energy. Moreover, when compared with other metal-based nanomaterials, Au-based nanomaterials are most widely used for this purpose, owing to the following advantages it offers: 1) a strong X-ray attenuation 1960 capability that makes it suitable for use in computer tomography (CT) imaging contrast agent and radiosensitizer [43][44][45] ; 2) as it can be easily surface-modified and embedded in structures such as liposomes and polymer particles, it is frequently used in different tumor treatment protocols; 3) as an inert metal, it exhibits good biocompatibility and low biotoxicity.…”

Bovine serum albumin and folic acid-modified aurum nanoparticles loaded with paclitaxel and curcumin enhance radiotherapy sensitization for esophageal cancer

“…Au NPs possess good surface modifiability and can be further used for reducing NP toxicity and improving biocompatibility in vivo through coating with specific protective molecules. Bovine serum albumin (BSA) is a common surface modifier for metal NPs 9 , and BSA-coated Au NPs (BSA-Au) have been widely used for tumor monitoring and treatment 10,11 . For instance, Murawala et al 12 prepared BSA-Au NPs loaded with methotrexate (MTX) and demonstrated that BSA-Au-MTX had a more significant inhibitory effect on breast cancer cells than an equivalent dose of free MTX.…”