Preparation of branched cyclomaltoheptaose with 3-O-α-l-fucopyranosyl-α-d-mannopyranose and changes in fucosylation of HCT116 cells treated with the fucose-modified cyclomaltoheptaose

Synthesis and Biological Evaluation of Novel Glycosyl-Containing 1,2,4-Triazolo[3,4-b][1,3,4]Thiadiazole Derivatives as Acetylcholinesterase Inhibitors

“…- [1,2,4]trazolo [3,4-b] [1,3,4] 3-Pyridyl-6- (1,3,4,6-tetra-O-benzyl-2-deoxy-β-d-glucopyranose-2-yl)- [1,2,4]triazolo [3,4-b][1,3,4] [1,2,4]triazolo [3,4-b][1,3,4] In vitro cholinesterase activity assay AChE inhibitory activity were measured through Ellman's colorimetric method with a slight modification. 33 Electric eel AChE was dissolved in phosphate-buffered saline (PBS, 0.1 M, pH 8.0) to obtain a solution of 0.35 U mL −1 .…”

“…

Carbohydrates have long interested chemists and biochemists as a large natural resource due to their predominant role in biological and industrial applications. [1][2][3][4] As an energy source and as a compound in many metabolic processes, sugars are present in every part of the human body. d-glucosamine is a naturally occurring amino sugar, 5,6 is one of the most abundant monosaccharides and has been widely used as an alternative medicine for the prevention and/or treatment of rheumatoid arthritis and osteoarthritis 7,8 .

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Direct and Regioselective Di‐α‐fucosylation on the Secondary Rim of β‐Cyclodextrin

“…[9] Most examples of chemically synthesized glycoclusters display the glycanso nt he primary rim, [10][11][12][13][14][15][16][17] and only af ew examples are reported of direct glycosylation of the C6 hydroxyls. [18][19][20][21] Alternatively,e nzymatic transglycosylation strategies resulted in the formation of am ixture of multiply glycosylated CDs, bearing a-galactosyl units on the C-2 or C-6 positiono ft he glucosides. [22,23] When two or more glycoside units were introduced, low regioselectivityw as observed.…”

“…As depicted in Scheme , CDs generally adopt the shape of a truncated cone, which has the C‐6 hydroxyls on the top (primary rim) and the C‐2 and C‐3 hydroxyls on the bottom of the cone (secondary rim, Scheme ) . Most examples of chemically synthesized glycoclusters display the glycans on the primary rim, and only a few examples are reported of direct glycosylation of the C6 hydroxyls . Alternatively, enzymatic transglycosylation strategies resulted in the formation of a mixture of multiply glycosylated CDs, bearing α‐galactosyl units on the C‐2 or C‐6 position of the glucosides .…”

Synthesis and bioactivity of novel C2-glycosyl oxadiazole derivatives as acetylcholinesterase inhibitors

“…Carbohydrates have long interested chemists and biochemists as a large natural resource [1][2][3][4]. As an energy source and an element of many metabolic processes, sugars are present in every part of the human body [5].…”