Preparation of biocompatible system based on electrospun CMC/PVA nanofibers as controlled release carrier of diclofenac sodium

El‐Newehy, Mohamed H.; El‐Naggar, Mehrez E.; Alotaiby, Saleh; El‐Hamshary, Hany; Moydeen, Meera; Al‐Deyab, Salem S.

doi:10.1080/10601325.2016.1201752

Cited by 79 publications

(27 citation statements)

References 22 publications

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“…PVA is chemically and thermally stable [44] and is resistant to degradation under most physiological environments [41]. Moreover, it is water-soluble due to its elevated polarity, non-toxicity [45], and high biocompatibility [46,47] and it can be processed easily [48]. PVA has also promising potential for producing biodegradable films [49].…”

Section: Abstract a R T I C L E I N F O R M A T I O Nmentioning

confidence: 99%

A review of Polyvinyl alcohol / Carboxiy methyl cellulose (PVA/CMC) composites for various applications

khoramabadi

Arefian

Hojjati

et al. 2020

jcc

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Polyvinyl alcohol/carboxymethyl cellulose (PVA/CMC) composites have attracted considerable attention due to the synergic relation between the two polymers and developing novel blends with improved properties. On one hand, PVA is a versatile polymer with higher mechanical properties compared to CMC. On the other hand, CMC has high biodegradability and biocompatibility, while suffering from poor mechanical properties. Therefore, the blending of the two polymers can help to benefit from the individual component properties. This paper has reviewed the properties and potential applications (e.g. drug delivery, food packaging, and agriculture) of the PVA/ CMC composites.

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Section: Abstract a R T I C L E I N F O R M A T I O Nmentioning

confidence: 99%

A review of Polyvinyl alcohol / Carboxiy methyl cellulose (PVA/CMC) composites for various applications

khoramabadi

Arefian

Hojjati

et al. 2020

jcc

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“…Some drugs such as insulin [20], paclitaxel [21], azithromycin [22], triamcinolone acetonide [23], methylprednisolone acetate [24], ibuprofen [25], naproxen [26], etc. [27][28][29][30][31][32][33][34] have been prepared by this method.…”

Section: Introductionmentioning

confidence: 99%

Morphological and physicochemical evaluation of the propranolol HCl–Eudragit^® RS100 electrosprayed nanoformulations

Garjani

Barzegar-Jalali

Osouli-Bostanabad

et al. 2017

Artificial Cells, Nanomedicine, and Biotechnology

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The aim of this study was to fabricate propranolol hydrochloride (Prop. HCl) (as a water-soluble drug):Eudragit RS100 (Eud) nanobeads and nanofibres applying the electrospraying method as an economical and one-step technique. Different ratios of Prop. HCl:Eud (i.e. 1:5 and 1:10) at total solution concentrations of 10-20% W/V were investigated. The FE-SEM studies revealed that morphology and size of the samples were highly affected by the solution concentration; so that, the nanobeads (a mean diameter of 82.9 nm) were formed in low concentration and at the highest concentration of the solution, nanofibres (a mean diameter of 232.3 nm) were resulted. Besides the morphological changes, the size of processed nanoformulations was increased with an increment of the solution concentrations. X-ray diffraction results as well as DSC thermograms clearly indicated that the drug crystallinity decreased in the electrosprayed samples. Furthermore, in vitro dissolution test showed that the electrosprayed samples had relatively slower release patterns toward the pure drug and physical mixtures, where the samples with the drug:polymer ratio of 1:10 indicated a faster release rate toward 1:5 ratio; nevertheless, the concentration of the injected formulations did not remarkably impressed the release behaviours. The current study established the suitability of electrospraying method in the fabrication of the water-soluble drugs nanobeads/nanofibres; however, in vivo effectiveness of the prepared nanoformulations should be meticulously considered.

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“…Sodium Carboxymethyl cellulose (CMC) is a plant based "green" and inexpensive natural polymer consisting of glycopyranose units with non-toxic, biocompatible, and biodegradable nature (El-Newehy et al, 2016). Due to being water soluble, CMC possesses both carboxylate and hydroxyl groups The pure Sodium Carboxymethyl cellulose is white or milk white fibrous powder or particles and tasteless.…”

Section: B-sodium Carboxymethyl Cellulosementioning

confidence: 99%

Stabilisation of clay soil with polymers through electrokinetic technique

Estabragh

Moghadas

Abdollahi

2019

European Journal of Environmental and Civil Engineering

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In this work the effect of migration of two polymers, namely polyethylene oxide (PEO) and sodium carboxymethyle cellulose (CMC) with concentrations of 2, 4 and 6 g/L on improvement of a clay soil is investigated through a program of experimental tests. The tests were conducted in a special apparatus under the voltage of 50 volt and over a period of 7 days. During each test, the values of pH and EC in the two reservoirs, discharge fluid from the cathode reservoir were measured at different time intervals. At the end of each test the strength of soil was measured across the length of sample. SEM tests were also carried out at the end of the test on the samples. The results showed that both polymers caused significant increase in the settlement and undrained shear strength of the soil but the maximum strength was obtained at concentration of 4 g/L. At this concentration the values pH and EC at the cathode reservoir were about 13 and 48 dS/m for both polymers.The SEM results revealed that the increase in strength is due to the covering of the particle surfaces and penetration of the polymer between the spaces of soil particles.

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Preparation of biocompatible system based on electrospun CMC/PVA nanofibers as controlled release carrier of diclofenac sodium

Cited by 79 publications

References 22 publications

A review of Polyvinyl alcohol / Carboxiy methyl cellulose (PVA/CMC) composites for various applications

A review of Polyvinyl alcohol / Carboxiy methyl cellulose (PVA/CMC) composites for various applications

Morphological and physicochemical evaluation of the propranolol HCl–Eudragit^® RS100 electrosprayed nanoformulations

Stabilisation of clay soil with polymers through electrokinetic technique

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Preparation of biocompatible system based on electrospun CMC/PVA nanofibers as controlled release carrier of diclofenac sodium

Cited by 79 publications

References 22 publications

A review of Polyvinyl alcohol / Carboxiy methyl cellulose (PVA/CMC) composites for various applications

A review of Polyvinyl alcohol / Carboxiy methyl cellulose (PVA/CMC) composites for various applications

Morphological and physicochemical evaluation of the propranolol HCl–Eudragit® RS100 electrosprayed nanoformulations

Stabilisation of clay soil with polymers through electrokinetic technique

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Product

Resources

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Morphological and physicochemical evaluation of the propranolol HCl–Eudragit^® RS100 electrosprayed nanoformulations