Preparation of astaxanthin micelles self-assembled by a mechanochemical method from hydroxypropyl β-cyclodextrin and glyceryl monostearate with enhanced antioxidant activity

Su, Wenjing; Polyakov, Nikolay E.; Xu, Wenhao; Su, Weike

doi:10.1016/j.ijpharm.2021.120799

Cited by 23 publications

(19 citation statements)

References 39 publications

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“…Generally, the colloid grinding method is especially suitable for poorly soluble guest substances and has obvious advantages such as saving, simplicity, high efficiency, and high quality [ 50 ]. Among the different techniques proposed for preparing CD inclusion complexes in the solid state, grinding appears as a fast, convenient, sustainable, and solvent-free method [ 51 , 52 , 53 ]. Alternatively, the disadvantage of the grinding method is that the production speed is slow, the yield is low, and the strength quickly affects the inclusion rate of the inclusion compound.…”

Section: Preparation Methods Of Cyclodextrins Inclusion Complexmentioning

confidence: 99%

Cyclodextrin Inclusion Complexes and Their Application in Food Safety Analysis: Recent Developments and Future Prospects

Zhou

Jia

et al. 2022

Foods

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Food safety issues are a major threat to public health and have attracted much attention. Therefore, exploring accurate, efficient, sensitive, and economical detection methods is necessary to ensure consumers’ health. In this regard, cyclodextrins (CDs) are promising candidates because they are nontoxic and noncaloric. The main body of CDs is a ring structure with hydrophobic cavity and hydrophilic exterior wall. Due to the above characteristics, CDs can encapsulate small guest molecules into their cavities, enhance their stability, avoid agglomeration and oxidation, and, at the same time, interact through hydrogen bonding and electrostatic interactions. Additionally, they can selectively capture the target molecules to be detected and improve the sensitivity of food detection. This review highlights recent advances in CD inclusion technology in food safety analysis, covering various applications from small molecule and heavy metal sensing to amino acid and microbial sensing. Finally, challenges and prospects for CDs and their derivatives are presented. The current review can provide a reference and guidance for current research on CDs in the food industry and may inspire breakthroughs in this field.

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Section: Preparation Methods Of Cyclodextrins Inclusion Complexmentioning

confidence: 99%

Cyclodextrin Inclusion Complexes and Their Application in Food Safety Analysis: Recent Developments and Future Prospects

Zhou

Jia

et al. 2022

Foods

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“…As a green and efficient method, mechanochemical solid-phase preparation technology is widely used to prepare solid dispersions and high-performance materials (Zhang et al., 2021 ; Su et al, 2021 ). In this report, the solid dispersion of IBU-PSP was prepared by green mechanochemical approaches based on solvent-free ball milling techniques.…”

Section: Methodsmentioning

confidence: 99%

Mechanochemical prepared ibuprofen-Polygonatum sibiricum polysaccharide drug delivery system for enhanced bioactivity with reduced renal injury induced by NSAIDs

Yang

et al. 2022

Drug Delivery

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Ibuprofen (IBU) was a widely used NSAID (a type of nonsteroidal anti-inflammatory drug) worldwide, and many drug deliveries had been reported to enhance bioavailability. However, higher bioavailability would increase the danger of renal injury caused by oxidative stress. This study prepared IBU- Polygonatum sibiricum polysaccharide (IBU-PSP) drug delivery system via mechanochemical method. Due to drug delivery and renal protection effect of Polygonatum sibiricum polysaccharide (PSP), the solubility of IBU-PSP was increased 8.22 times, and the bioavailability was increased 2.52 times compared with IBU, carrageenin-induced rat paw edema test also increased. Meanwhile, short-term and long-term renal injuries induced by IBU were notable decreases. In conclusion, IBU-PSP was a multifunctional drug delivery system with superior anti-inflammatory and renal protection effects. It will benefit from developing high-efficiency NADIs preparations with safer clinical applications while providing an efficient and energy-saving technology for polysaccharide drug delivery.

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“…They are formed spontaneously, from amphiphilic molecules or surfactant agents at specific concentrations and temperatures [49]. In a recent study, an astaxanthin HPβCD inclusion complex that self-assembled into micelles in an aqueous solution was prepared, and achieved solid-phase loading of the drug by Su et al [75]. The authors improved the aggregation characteristics of the micelles by adding a small flexible substance, glyceryl monostearate, improving the solubility and antioxidant activity of the drug.…”

Section: Lipid Micellesmentioning

confidence: 99%

Cyclodextrin-Modified Nanomaterials for Drug Delivery: Classification and Advances in Controlled Release and Bioavailability

et al. 2021

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In drug delivery, one widely used way of overcoming the biopharmaceutical problems present in several active pharmaceutical ingredients, such as poor aqueous solubility, early instability, and low bioavailability, is the formation of inclusion compounds with cyclodextrins (CD). In recent years, the use of CD derivatives in combination with nanomaterials has shown to be a promising strategy for formulating new, optimized systems. The goals of this review are to give in-depth knowledge and critical appraisal of the main CD-modified or CD-based nanomaterials for drug delivery, such as lipid-based nanocarriers, natural and synthetic polymeric nanocarriers, nanosponges, graphene derivatives, mesoporous silica nanoparticles, plasmonic and magnetic nanoparticles, quantum dots and other miscellaneous systems such as nanovalves, metal-organic frameworks, Janus nanoparticles, and nanofibers. Special attention is given to nanosystems that achieve controlled drug release and increase their bioavailability during in vivo studies.

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Preparation of astaxanthin micelles self-assembled by a mechanochemical method from hydroxypropyl β-cyclodextrin and glyceryl monostearate with enhanced antioxidant activity

Cited by 23 publications

References 39 publications

Cyclodextrin Inclusion Complexes and Their Application in Food Safety Analysis: Recent Developments and Future Prospects

Cyclodextrin Inclusion Complexes and Their Application in Food Safety Analysis: Recent Developments and Future Prospects

Mechanochemical prepared ibuprofen-Polygonatum sibiricum polysaccharide drug delivery system for enhanced bioactivity with reduced renal injury induced by NSAIDs

Cyclodextrin-Modified Nanomaterials for Drug Delivery: Classification and Advances in Controlled Release and Bioavailability

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