Preparation of antimicrobial polycarboxybetaine‐based hydrogels for studies of drug loading and release

Abstract

A series of cationic poly(N‐isopropyl acrylamide) (PNIPAM)‐g‐poly(carboxybetaine ester) (PCBMAE) hydrogels were prepared by reversible addition–fragmentation chain‐transfer polymerization with PCBMAE precursors reacting with N‐isopropyl acrylamide in the presence of N,N′‐methylene bisacrylamide. These hydrogels exhibited excellent antimicrobial activities against Staphylococcus aureus and could switch to nontoxic zwitterionic hydrogels after hydrolysis. Nonionic tetracycline hydrochloride (TCHC) and anionic sodium salicylate (SA) were selected to evaluate the loading capacities and release kinetics of the cationic hydrogels. We found that the loading efficiencies of TCHC in the PNIPAM‐g‐PCBMAE hydrogels were approximately twice as high as those of SA. However, the cumulative release amount of TCHC was lower than that of SA from the corresponding cationic hydrogel at 37°C. In addition, the PNIPAM‐g‐PCBMAE hydrogels exhibited accelerated release rates of both TCHC and SA with increasing content of (2‐carboxymethyl)−3‐acryloxyethyldimethylammonium chloride methyl ester. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 39839.

Facile Fabrication of Cellulose Nanofibrils/Chitosan Beads as the Potential pH-Sensitive Drug Carriers

“…Also, the release amount of CNF/CS beads (8:2) in the first 1 h of releasing under acid conditions (14.5%) was lower than other reported TH carriers, such as polydopamine/CNF hydrogel (20%) [ 6 ], collagen hydrogel (42%) [ 32 ], polycarboxybetaine hydrogel (35%) [ 33 ], and hyaluronic acid/alginate scaffolds (50%) [ 34 ]. Simultaneously, the total release amount of TH from CNF/CS beads (8:2) (88%) was higher than many reported TH carriers, such as polydopamine/CNF hydrogel (77%) [ 6 ], collagen hydrogel (50%) [ 32 ], and cellulose nanocrystal (82.2%) [ 35 ].…”

Examination of fabrication conditions of acrylate-based hydrogel formulations for doxorubicin release and efficacy test for hepatocellular carcinoma cell

“…This can be explained by inclusion complex formation between doxorubicin and polymer networks during loading process, and these internal interactions at high polymer ratio may provide a force to prevent the drug molecules from releasing and resulted in low percent cumulative release. [41,42] This could not be a case for the high drug-loaded formulations where the cumulative releases were higher about 18-37% compared to low drug-loaded counterparts in the time frame of the experiment. At high loading, only a small portion of the drug could be interacted with the polymer network, and remaining drug could be freely suspended in the vicinity of the polymer networks.…”

Preparation of Antimicrobial PHEMA-<i>g</i>-PCBMAE Hydrogels with Improved Mechanical Properties

“…Polycarboxybetaine methacrylate ester(PCBMAE) hydrogel is a novel biocompatible material which can reach the requirements of implantable biomaterials [5]. These hydrogels were shown to exhibit good antimicrobial activities of 99.8% against Staphylococcus aureus [6] and kill 99.9 % of Escherichia coliK12 in 1h [4]. However, this hydrogel becomes very brittle when it is fully swollen.…”