“…In response surface experimental, RSM using BBD was employed to investigate the relationship between three independent variables (X1, concentration of sodium alginate; X2, concentration of sodium pyrophosphate; X3, concentration of TP) that was code at three levels (-1, 0, 1) and six dependent variables (Y1, longitudinal tensile force; Y2, transverse tensile force; Y3, longitudinal tensile strength; Y4, transverse tensile strength; Y5, longitudinal elongation at break; Y6, transverse elongation at break) of collagen casings in this study (Table 1). All the ranges of the parameters in RSM were selected based on the results of single factor experiments according to our previous study (Xie et al, 2020). The concentrations of sodium alginate, sodium pyrophosphate and TP varied from 2.5 to 3.5%, 2.5 to 3.5% and 1.5 to 2.5%, respectively.…”