Preparation of antibacterial polypeptides with different topologies and their antibacterial properties

Abstract

Antimicrobial peptides (AMPs) are attractive antimicrobial agents used to combat bacterial infections and have been advanced to be one of the most promising alternatives to conventional antibiotics. They stand out...

Recent Advance in Polymer Coatings Combating Bacterial Adhesion and Biofilm Formation†

“…prepared a series of amphiphilic and cationic polypeptides with F and K residues and different topological structures ( i.e ., linear or star‐shaped). [ 71 ] The polypeptides were covalently immobilized on epoxy group modified glass surfaces by the amine‐epoxy reaction. Both linear and star‐shaped polypeptide coatings showed a rapid‐acting antibacterial activity that more than 90% bacteria were inhibited by the coatings within 10 min.…”

Kidney‐Targeted Nanoparticles Loaded with the Natural Antioxidant Rosmarinic Acid for Acute Kidney Injury Treatment

“…[19,38] PAMAM, bearing long and soft chains at their periphery, is the most promising polyamine cationic dendrimers in the field of biomedicine, as a carrier of drugs, genes, and vaccines for sustained and targeted drug release. [39,40] PAMAM dendrimers include three architectural components: a reactant core molecule, highly branched polymeric layers, and a multivalent periphery. [41] Thanks to its embellished surface functionalities and significant internal cavities, it can be widely used for drug and gene delivery applications.…”

Self-Assembled Cationic Nanoparticles Combined with Curcumin against Multidrug-Resistant Bacteria

“… 27 − 29 The unmatched sterilization mode makes it difficult for bacteria to develop drug resistance. 30 In addition, with the rapid development of nanotechnology in the past few decades, antibacterial nanomaterials have also attracted great attention recently because of their unique properties such as ultra-small size and good biocompatibility. 13 , 19 , 31 − 34 …”

“…Toward this goal, a large number of macromolecular antibacterial materials, such as quaternary ammonium moieties, carbon-based nanomaterials, antibacterial peptides, and N -halamine polymers, have been widely studied. ,− These materials carry enriched antibacterial groups and have better selectivity toward bacteria than mammalian cells . Especially, cationic polymers with amphiphilic structures have attracted wide attention as the most promising substitutes for antibiotics because they have excellent activities and rapid onset of killing and are less prone to develop drug resistance, and so on. − Amphiphilic cationic polymers can bind to bacterial membranes via electrostatic interactions, prompting the hydrophobic groups in polymers to penetrate into the lipophilic domain of the membranes and then tear the membranes, eventually leading to the leakage of intracellular contents and lysis of bacterial cells. − The unmatched sterilization mode makes it difficult for bacteria to develop drug resistance . In addition, with the rapid development of nanotechnology in the past few decades, antibacterial nanomaterials have also attracted great attention recently because of their unique properties such as ultra-small size and good biocompatibility. ,,− …”

“…27−29 sterilization mode makes it difficult for bacteria to develop drug resistance. 30 In addition, with the rapid development of nanotechnology in the past few decades, antibacterial nanomaterials have also attracted great attention recently because of their unique properties such as ultra-small size and good biocompatibility. 13,19,31−34 Amphiphilic polymers composed of hydrophilic and hydrophobic sections could self-assemble into nanoparticles with core−shell structures, 29,35−38 which can improve the antibacterial activities and biocompatibility of the polymers.…”