Preparation of an oral thin film containing meclizine hydrochloride: In vitro and in vivo evaluation

Yuan, Zhao; Quan, Peng; Fang, Liang

doi:10.1016/j.ijpharm.2015.10.008

Cited by 24 publications

(5 citation statements)

References 19 publications

(12 reference statements)

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“…FTIR spectra of pure drug Meclizine hydrochloride was recorded by suspending in liquid paraffin and placing in sodium chloride cell on FTIR spectrophotometer (IR Affinity, Shimadzu, Japan). The peaks were determined and observed peaks were compared with standard 8 .…”

Section: Methodsmentioning

confidence: 99%

“…Meclizine hydrochloride (MHCl) is an antihistamine drug used to prevent and treat nausea and vomiting associated with a variety of conditions including motion sickness and treatment that is symptomatic of vertigo caused by ménière syndrome and an overactive sensory response. The drug should be taken early, thereby improving patient compliance, improving bioavailability and ISSN: 2250-1177 [8] CODEN (USA): JDDTAO lowering the dose. The Oro-dispersible tablet is defined in the form of direct pressure that uses super disintegrates at various levels.…”

Section: Introductionmentioning

confidence: 99%

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Development of Oro-Dispersible Tablet of Meclizine by Using Different Superdisintegrating Agents

Kumar¹,

Jain²,

Yadav³

et al. 2022

J. Drug Delivery Ther.

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The proposed study is development of oro-dispersible tablet containing meclizine hydrochloride solid dispersion (FMODDs) formulation with using natural superdisintegrant with direct compression. The superdisintegrants and its concentration shall be during the preparation of FMODDs with meclizine hydrochloride by using direct compression via employing different excipients in different ratio including: superdisintegrants {sodium starch glycolate (SSG), Ac-Di-Sol, crosspovidone (CP), Spray dried lactose and microcrystalline cellulose (MCC)} which were used alone and in various combination and mannitol, along with lubricant and glidants. The object of proposed work was preparation of FMODDs with a short disintegration time, sufficient mechanical strength, better patient compliance, and acceptable stability profile by employing different methods of preparation and studying different variables affecting pre and post-compression parameters of formulas of meclizine hydrochloride. The combination of agents have more disintegrating property due to rapid water uptake and dispersion time which lead to rapid release of drug and made the dissolution faster. The results of the release kinetics study showed that all the formulations obeyed first order drug release profile more closely, i.e., the release rate depended upon the initial concentration of drug. Keywords: Solid dispersion, Oro-dispersible, Fast disintegration, Direct compressed tablet, Meclizine hydrochloride, Superdisintegranting agents

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Development of Oro-Dispersible Tablet of Meclizine by Using Different Superdisintegrating Agents

Kumar¹,

Jain²,

Yadav³

et al. 2022

J. Drug Delivery Ther.

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“…Indeed, chitosan and sodium carboxymethylcellulose oral films were previously optimised by our group but disintegration times were much higher and drug release was very distinct from developed guar-gum films [28]. Indeed, mechanical characteristics are very important either to assure stability during transport, accurate dosage of carried bioactive molecules or to avoid handling and administration issues [32].…”

Section: Optimization Of the Formulation Of Guar-gum Oral Films And Vmentioning

confidence: 99%

Incorporation of beads into oral films for buccal and oral delivery of bioactive molecules

Castro

Sousa

Magalhães

et al. 2018

Carbohydrate Polymers

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The association of alginate beads and guar-gum films in a single delivery system was idealized to promote a more effective buccal and oral delivery of bioactive molecules. A response surface method (experimental design approach) was performed to obtain optimal formulations of alginate beads to be incorporated into guar gum oral films as combined buccal and oral delivery systems for caffeine delivery. The combined formulation was further characterized regarding physicochemical properties, drug release, cell viability and buccal permeability. Beads average size, determined by dynamic light scattering (DLS), was of 3.37 ± 6.36 μm. Film thickness was set to 62 μm. Scanning electron microscopy micrographs revealed that beads were evenly distributed onto the film matrix and beads size was in accordance to data obtained from DLS analysis. Evaluation of Fourier-transform infrared spectra did not indicate the formation of new covalent bonds between the matrix of guar-gum films, alginate beads and caffeine. In vitro release assays by dialysis membrane allowed understanding that the combination of guar-gum films and alginate beads assure a slower release of caffeine when compared with the delivery profile of free caffeine from alginate beads or guar-gum films alone. MTT assay, performed on human buccal carcinoma TR146 cell line, allowed concluding that neither guar-gum film, alginate beads nor guar-gum film incorporated into alginate beads significantly compromised cell viability after 12 h of exposure. As demonstrated by in vitro permeability assay using TR146 human buccal carcinoma cell lines, combination of guar-gum films and alginate beads also promoted a slower release and, thus, lower apparent permeability (1.15E-05 ± 3.50E-06) than for caffeine solution (2.68E-05 ± 7.30E-06), guar-gum film (3.12E-05 ± 4.70E-06) or alginate beads (2.01E-05 ± 3.90E-06). The conjugation of alginate beads within an orodispersible film matrix represents an effective oral/buccal delivery system that induces a controlled release along with an enhanced intimate contact with cell layers that may promote higher in vivo bioavailability of carried drugs.

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“…Recent research has established polymer-based films as a drug delivery platform with several advantages over traditional solid oral dosage forms [1][2][3][4][5][6][7][8][9][10]. The polymer films are considered to be patient compliant and self-administrable, particularly among pediatric and geriatric patients.…”

Section: Introductionmentioning

confidence: 99%

Impact of Mixing on Content Uniformity of Thin Polymer Films Containing Drug Micro-Doses

et al. 2021

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The impact of mixer type and critical process parameters (CPPs) on critical quality attributes (CQAs), including the drug content uniformity (CU) of slurry-cast polymer films loaded with micro-sized poorly water-soluble drugs were investigated. Previously untested hypothesis was that the best mixer at suitable CPPs promotes uniform drug dispersion within film precursors leading to acceptable dried-film CU at low, ~0.6 wt% drug concentrations. Taguchi design was utilized to select the best of three mixers; low-shear impeller, high-shear planetary, and high-intensity vibrational, for dried-film drug concentration of ~23 wt%. As-received fenofibrate, a model poorly water-soluble drug (~6 µm) was directly mixed with the hydroxypropyl methylcellulose (HPMC) and glycerin aqueous solution. Impeller and planetary mixers yielded desirable film relative standard deviation (RSD), while vibrational mixer could not. For the lowest dried-film drug concentration of ~0.6 wt%, only planetary mixer yielded RSD <6%. The precursor drug homogeneity was a sufficient but not a necessary condition for achieving dried-film RSD <6%. Thus, proper selection of mixer and its CPPs assured desirable film CQAs. However, minor drug particle aggregation was identified via re-dispersion testing which also led to incomplete drug release.

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Preparation of an oral thin film containing meclizine hydrochloride: In vitro and in vivo evaluation

Cited by 24 publications

References 19 publications

Development of Oro-Dispersible Tablet of Meclizine by Using Different Superdisintegrating Agents

Development of Oro-Dispersible Tablet of Meclizine by Using Different Superdisintegrating Agents

Incorporation of beads into oral films for buccal and oral delivery of bioactive molecules

Impact of Mixing on Content Uniformity of Thin Polymer Films Containing Drug Micro-Doses

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