Preparation of an injectable hydrogel reinforced by graphene oxide and its application in dye wastewater treatment

Huang, Qian; Zhou, Yiming; Fu, Zhiwei; Zhu, Jiajing

doi:10.1007/s10853-023-08213-z

Cited by 5 publications

(2 citation statements)

References 53 publications

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“…Stimuli-responsive hydrogels, also known as "smart" hydrogels, are materials that respond to various stimuli (pH, temperature, light, ionic strength, magnetic, redox, electric, and chemical response), exhibiting reversible changes in their chemical and physical state [1][2][3][4]. Due to their soft texture, elasticity, biocompatibility, high swelling capability, and similarity to body tissues, hydrogels are ideal candidates for use as biomaterials in a variety of applications [5,6] like delivery of drugs and other bioactive ingredients [7][8][9][10][11][12][13][14][15][16], 3D printing [17][18][19][20], tissue engineering, repair and regeneration [21][22][23][24], or shear-thinning injectable matrices for bioapplications [25,26].…”

Section: Introductionmentioning

confidence: 99%

A Remarkable Impact of pH on the Thermo-Responsive Properties of Alginate-Based Composite Hydrogels Incorporating P2VP-PEO Micellar Nanoparticles

Iliopoulou,

Iatridi,

Tsitsilianis

2024

Polymers

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A heterograft copolymer with an alginate backbone, hetero-grafted by polymer pendant chains displaying different lower critical solution temperatures (LCSTs), combined with a pH-responsive poly(2-vinyl pyridine)-b-poly(ethylene oxide) (P2VP-b-PEO) diblock copolymer forming micellar nanoparticles, was investigated in aqueous media at various pHs. Due to its thermo-responsive side chains, the copolymer forms hydrogels with a thermo-induced sol–gel transition, above a critical temperature, Tgel (thermo-thickening). However, by lowering the pH of the medium in an acidic regime, a remarkable increase in the elasticity of the formulation was observed. This effect was more pronounced in low temperatures (below Tgel), suggesting secondary physical crosslinking, which induces significant changes in the hydrogel thermo-responsiveness, transforming the sol–gel transition to soft gel–strong gel. Moreover, the onset of thermo-thickening shifted to lower temperatures followed by the broadening of the transition zone, implying intermolecular interactions between the uncharged alginate backbone with the PNIPAM side chains, likely through H-bonding. The shear-thinning behavior of the soft gel in low temperatures provides injectability, which allows potential applications for 3D printing. Furthermore, the heterograft copolymer/nanoparticles composite hydrogel, encapsulating a model hydrophobic drug in the hydrophobic cores of the nanoparticles, was evaluated as a pH-responsive drug delivery system. The presented tunable drug delivery system might be useful for biomedical potential applications.

show abstract

Section: Introductionmentioning

confidence: 99%

A Remarkable Impact of pH on the Thermo-Responsive Properties of Alginate-Based Composite Hydrogels Incorporating P2VP-PEO Micellar Nanoparticles

Iliopoulou,

Iatridi,

Tsitsilianis

2024

Polymers

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show abstract

“…Stimuli responsive hydrogels, also known as "smart" hydrogels, are materials that respond to various stimuli (pH, temperature, light, ionic strength, magnetic, redox, electric, chemical response) exhibiting reversible changes in their chemical and physical state [1−4]. Due to their soft texture, elasticity, biocompatibility, high swelling capability and similarity to body tissues, hydrogels are ideal candidates for use as biomaterials in a variety of applications [5,6] like delivery of drugs and other bioactive ingredients [7−16], 3D printing [17−20], tissue engineering, repair and regeneration [21−24], or shear-thinning injectable matrices for bioapplications [25,26].…”

Section: Introductionmentioning

confidence: 99%

A Remarkable Impact of pH to the Thermoresponsive Properties of Alginate-Based Composite Hydrogels Incorporating P2VP-PEO Micellar Nanoparticles

Iliopoulou,

Iatridi,

Tsitsilianis

2024

Preprint

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A heterograft copolymer with an alginate backbone, hetero-grafted by polymer pendant chains displaying different Lower Critical Solution Temperatures (LCSTs), combined with a pH-responsive Poly(2-vinyl pyridine)-b-poly(ethylene oxide) (P2VP-b-PEO) diblock copolymer forming micellar nanoparticles, was investigated in aqueous media at various pH. Due to its thermoresponsive side chains, the copolymer forms hydrogels with thermo–induced sol–gel transition, above a critical temperature, Tgel (thermo–thickening). However, by lowering pH of the medium in acidic regime, a remarkable increase of the elasticity of the formulation was observed. This effect was more pronounced in low temperatures (below Tgel) suggesting secondary physical crosslinking, which induces significant changes in the hydrogel thermoresponsiveness, transforming the sol–gel transition to soft gel–strong gel. Moreover, the onset of thermothickening shifted to lower temperatures followed by broadening of the transition zone, implying intermolecular interactions between the uncharged alginate backbone with the PNIPAM side chains, likely through H–bonding. The shear–thinning behavior of the soft gel in low temperatures provides injectability, which allows 3D–printing potential applications. Furthermore, the heterograft copolymer/nanoparticles composite hydrogel, encapsulating a model hydrophobic drug in the hydrophobic cores of the nanoparticles, was evaluated as pH-responsive drug delivery system. The presented tunable drug delivery system might be useful for biomedical potential applications.

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Rapid fabrication of porous κ-carrageenan/cellulose nanofibrils-polydopamine composite hydrogels induced by ionic interaction for flexible electronic devices

Chen,

Zhou,

et al. 2023

European Polymer Journal

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Preparation of an injectable hydrogel reinforced by graphene oxide and its application in dye wastewater treatment

Cited by 5 publications

References 53 publications

A Remarkable Impact of pH on the Thermo-Responsive Properties of Alginate-Based Composite Hydrogels Incorporating P2VP-PEO Micellar Nanoparticles

A Remarkable Impact of pH on the Thermo-Responsive Properties of Alginate-Based Composite Hydrogels Incorporating P2VP-PEO Micellar Nanoparticles

A Remarkable Impact of pH to the Thermoresponsive Properties of Alginate-Based Composite Hydrogels Incorporating P2VP-PEO Micellar Nanoparticles

Rapid fabrication of porous κ-carrageenan/cellulose nanofibrils-polydopamine composite hydrogels induced by ionic interaction for flexible electronic devices

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