Preparation of an inactivated penta cell culture vaccine against canine distemper, canine parvo, canine hepatitis "canine adeno-1", canine adeno-2 and rabies viruses for dogs

Abstract

A penta-dog inactivated cell culture vaccine was prepared to protect dogs against canine distemper virus, canine parvovirus, canine adenovirus1, 2 and rabies virus. The potency of this vaccine was compared with that of single inactivated vaccines prepared against each disease, in different groups of susceptible dogs. It was found that the protective dose of penta-dog vaccine (2ml) including the protective amounts of the five viral proteins resulted in full protection of vaccinated dogs against the challenge with virulent strain of the used viruses showing no antagonizing effect between each other with and no adverse postvaccinal reaction. So, the prepared inactivated cell culture penta-dog vaccine is a safe and potent vaccine for dogs which resulted in saving time, cost, and effort stress factors on animals and providing good immune statues.

Genotyping and phylogenetic analysis of canine parvovirus circulating in Egypt

“…In Egypt, the virus was initially reported in 1982, in military police dogs showing clinical manifestations, pathological outcomes [6] and CPV antibodies were detected by the serological study in spring months [7]. In 2005, a Penta Dog inactivated cell culture vaccine containing CPV was prepared [8]. In addition, the effect of different adjuvants on the inactivated canine parvo vaccine was investigated [9].…”