Preparation of amphiphilic copolymers via base-catalyzed hydrolysis of quaternized poly[2-(dimethylamino)ethyl methacrylate]

Abstract

The multi-stimuli-responsiveness of tertiary amine-containing polyacrylates makes them highly attractive for use in a wide range of applications. In the last decade, poly[2-(dimethylamino)ethyl methacrylate] (PDMAEMA) has received exceptionally large attention...

Two-way CO2-responsive dispersions of carbon nanotubes in water

“…In our previous report, we comprehensively investigated a sequence of two reactions that allowed the transformation of PDMAEMA into PMAA. 28 It was demonstrated that the PDMAEMA, which was highly stable to hydrolysis, if first quaternized into qPDMAEMA using methyl iodide, could be easily converted into PMAA via alkaline hydrolysis. The procedures of PDMAEMA synthesis via ATRP and its consecutive quaternization and hydrolysis were reproduced as previously described.…”

The influence of monomer ionization and hydrolysis on the radical polymerization kinetics of 2-(dimethylamino)ethyl methacrylate in aqueous solution

“…32 The orders-of-magnitude increased stability of poly(DMAEMA) compared to DMAEMA monomer is in stark contrast to the 2-(dimethylamino)ethyl acrylate system, for which both monomer and polymer units are equally susceptible to hydrolysis. 32 Further studies by Hoogeveen et al 31 and Shevtsov et al 33 also demonstrated that poly(DMAEMA) is stable, with the ester linkages protected against hydrolysis by the hydrophobic methacrylate polymer backbone. 32 The combined influence of pH and temperature on monomer hydrolysis has not been studied at the temperatures typically used for radical polymerization.…”

Polyacrylamide/poly(2-(dimethylamino) Ethyl Methacrylate) Interpenetrating Polymer Networks as Drug Delivery Systems for Diclofenac Sodium

“…To our best knowledge, polymeric carriers based on PDMAEMA and PAAm, including their IPNs, have been used so far as neither drug carriers nor, in particular, as diclofenac sodium carriers. These two polymers were chosen due to the fact that they have been reported to be non-toxic and biocompatible, and they have been widely used in recent years for the preparation of drug delivery systems [ 20 , 21 , 22 , 23 , 24 , 25 , 26 ]. It should be mentioned that PDMAEMA swells to a great extent in the stomach due to its pH-sensitive swelling behavior, which makes it inappropriate for oral drug delivery [ 27 , 28 ].…”