Preparation of aminoglycoside-loaded chitosan nanoparticles using dextran sulphate as a counterion

Lu, Enxian; Franzblau, Scott G.; Önyüksel, Hayat; Popescu, Carmen

doi:10.1080/02652040802365182

Cited by 59 publications

(52 citation statements)

References 23 publications

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“…Daily administration of chitosan-coated streptomycin/dextran sulfate complexes for 3 weeks decreases 15% bacterial levels; the same result obtained for similar schedule of subcutaneous administration of free drug (Lu et al, 2009) Gelatin Rifampicin Nanoparticles Mice Intravenous…”

Section: Guinea Pigs Pulmonarysupporting

confidence: 54%

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Natural carriers for application in tuberculosis treatment

Costa

Grenha

2012

Journal of Microencapsulation

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Section: Guinea Pigs Pulmonarysupporting

confidence: 54%

“…In one case, chitosan-coated complexes of streptomycin and dextran sulfate (500 nm) (Lu et al, 2009). The efficacy of the formulation is substantially lower than that observed for alginate formulations presented before and, unfortunately, controls such as the oral administration of free drug, for instance, were not reported.…”

Section: Polymeric Nanoparticlesmentioning

confidence: 94%

Natural carriers for application in tuberculosis treatment

Costa

Grenha

2012

Journal of Microencapsulation

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“…Gentamicin have been previously examined in a wide variety of nanoparticle delivery systems, including poly(lactide-co-glycolide) (PLGA), chitosan, and caroboxymethyldextran-b-poly(ethyleneglycols). [12][13][14] The application of antibiotic nanoparticle formulations has been shown to offer several advantages over conventional administration and delivery methods, including the ability for drug delivery to a specific site such as an intracellular infection. 15,16 Nanoparticles can also be exploited to facilitate sustained release of an antibiotic, minimizing dosing regimens.…”

Section: Introductionmentioning

confidence: 99%

“…18 Moreover, polymeric nanoparticles have shown to enhance the oral bioavailability of orally inactive antibiotics. 13 PLGA polymers have been used to entrap several antibiotics in nanoparticle formulations, demonstrating improved delivery and antibiotic efficacy. [19][20][21] Although encapsulation and the biological usefulness of gentamicin in PLGA have been previously reported, encapsulation efficiencies have been modest.…”

Section: Introductionmentioning

confidence: 99%

Gentamicin-loaded nanoparticles show improved antimicrobial effects towards Pseudomonas aeruginosa infection

Abdelghany¹,

Quinn²,

Ingram³

et al. 2012

IJN

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Abstract:Gentamicin is an aminoglycoside antibiotic commonly used for treating Pseudomonas infections, but its use is limited by a relatively short half-life. In this investigation, developed a controlled-release gentamicin formulation using poly(lactide-co-glycolide) (PLGA) nanoparticles. We demonstrate that entrapment of the hydrophilic drug into a hydrophobic PLGA polymer can be improved by increasing the pH of the formulation, reducing the hydrophilicity of the drug and thus enhancing entrapment, achieving levels of up to 22.4 µg/mg PLGA. Under standard incubation conditions, these particles exhibited controlled release of gentamicin for up to 16 days. These particles were tested against both planktonic and biofilm cultures of P. aeruginosa PA01 in vitro, as well as in a 96-hour peritoneal murine infection model. In this model, the particles elicited significantly improved antimicrobial effects as determined by lower plasma and peritoneal lavage colony-forming units and corresponding reductions of the surrogate inflammatory indicators interleukin-6 and myeloperoxidase compared to free drug administration by 96 hours. These data highlight that the controlled release of gentamicin may be applicable for treating Pseudomonas infections.

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“…Due to its biocompatibility, biodegradability and non-toxicity, chitosan has increasingly been used in the biomedical and pharmaceutical fields [1][2][3][4]. Chemical modifications have been used to prepare chitosan derivatives with enhanced biological and physicochemical properties.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of neomycin functionalized chitosan stabilized silver nanoparticles and study its antimicrobial activity

Preethika¹,

Ramya²,

Muthusamy³

et al. 2016

Nanosystems: Phys. Chem. Math.

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A simple green method was developed for the synthesis of silver nanoparticles in the presence of a neomycin-functionalized chitosan as stabilizing agent using a fresh lemon juice as green reducing agent. The stabilizing agent was synthesized based on the Schiff base formation reaction between the chitosan dialdehyde and neomycin antibiotic in 0.05 mM at pH 7.0. The combined form of neomycin antibiotic with chitosan can be used as stabilizing agent for silver nanoparticles (AgNPs) synthesized by a biogenic method using lemon juice as a green reducing agent. The neomycin functionalized chitosan stabilized AgNPs were characterized by various analytical techniques, including UVVisible spectra studies, FTIR, XRD and SEM. The antimicrobial activity of these composite was tested against human pathogenic Gram-positive and Gram-negative bacteria. The synergetic effect of the neomycin functionalized chitosan protected silver nanoparticles was tested against various drug resistant microorganisms. These chitosan derivatives can be used in combination with an anti-bacterial agent to treat and inhibit a resistant bacterial infection or the growth of resistant bacterial infection.

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Preparation of aminoglycoside-loaded chitosan nanoparticles using dextran sulphate as a counterion

Cited by 59 publications

References 23 publications

Natural carriers for application in tuberculosis treatment

Natural carriers for application in tuberculosis treatment

Gentamicin-loaded nanoparticles show improved antimicrobial effects towards Pseudomonas aeruginosa infection

Synthesis and characterization of neomycin functionalized chitosan stabilized silver nanoparticles and study its antimicrobial activity

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