Preparation of a Zirconium-89 Labeled Clickable DOTA Complex and Its Antibody Conjugate
Falguni Basuli,
Olga Vasalatiy,
Jianfeng Shi
et al.
Abstract:Desferrioxamine B (DFO) is the clinical standard chelator for preparing zirconium-89 labeled antibodies. In the current study, the stabilities of a zirconium-89 labeled panitumumab (PAN; Vectibix®) with three different chelators (DFO, DFO*, and DOTA) were compared. PAN is an anti-HER1/EGFR monoclonal antibody approved by the FDA for the treatment of HER1-expressing colorectal cancers and was used as the model antibody for this study. DFO/DFO* conjugates of PAN were directly radiolabeled with zirconium-89 at ro… Show more
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