Preparation of a sterile closed system99mTc generator based on zirconium molybdate

Reactor Production of Radionuclides for Generators

“…Alumina column; solvent extraction of pertechnetate [2,7,16]; sublimation [10,13,19]; zirconium molybdate gel [5,10,12]; titanium molybdate gel [11,17,18]. Cost: 120-150$ Ci -1 ; sterile generators: 150-250$.…”

“…Specific activities ranging from a few Ci per gram to several Ci per milligram of the parent are generally used for generators suited for reliable repeated elutions. The specific activity of the parent, however, needs not to be very high if the parent element is converted into a column matrix, as in the case of the gel generators for 99m Tc [5,11,12,18],…”

99mTc Gel Generators Based on Zirconium Molybdate-99Mo: I. Process Standardisation for Production

“…A major deterrent to the adaption of the ZrMo gel generator system, especially by developing countries, is the requirement of elaborate remote handling facilities (hot-cell and good degree of automation) for carrying out the complex gel processing steps, involving handling of radioactivity through the stages of precipitation, drying, grinding, sieving and dispensing of granules into individual columns. Our earlier experience with the ZrMo generator system [3] and later on with TiMo system [8] had revealed that the temperature and duration of drying were crucial to obtain an elutable column matrix, high " m Tc yield and reproducibility. It was envisaged that a drying technique which is rapid, involves minimal handling and transfer of precipitate and circumvents the cumbersome grinding and sieving steps would hold the key to success at remotisation [11,12], This paper describes our success at drying the ZrMo cake using a regulated flow of air heated in a controlled manner, which eventually led to the standardisation of a process for production of 5-10 generators per batch in a lead shielded plant adapting simple, ingenious techniques.…”

“…The early encouraging findings by Australian [1,2] and Indian [3][4][5] researchers through the metallic molybdate gel route paved the way for extensive and systematic studies using this approach. While the pioneer Australian scientists vigorously pursued the concept of conversion of (n,y) produced "Mo to zirconium molybdate-"Mo (Zr"Mo) gel [6,7], the Indian efforts were concentrated on the use of neutron irradiated titanium molybdate (TiMo) as column matrix [8].…”

High radioactive concentration of 99mTc from a zirconium [99Mo]molybdate gel generator using an acidic alumina column for purification and concentration

“…The development of a user-friendly, column-type 99m Tc generator based on the conversion of (n,g) 99 Mo as a zirconium [ 99 Mo]molybdate (Zr 99 Mo) matrix and subsequent elution of 99m Tc from the Zr 99 Mo gel column with normal saline is a well explored attractive alternative [7][8][9][10][11]. We have demonstrated the good performance and applicability of such generators for hospital radiopharmacies [12].…”