Preparation of a novel PEG–clay hybrid as a DDS material: Dispersion stability and sustained release profiles

Takahashi, Tetsuo; Yamada, Yoshiaki; Kataoka, Kazunori; Nagasaki, Yukio

doi:10.1016/j.jconrel.2005.03.031

Cited by 123 publications

(96 citation statements)

References 19 publications

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“…Since the use of ligand-conjugated QDs as fluorescent biolabeling reagents was reported in 1998 by the groups of Alivisatos [51] and Nie [52], many approaches to QD applications have been realized in the bioanalytical field such as DNA sequencing, tissue immune-diagnostics and single molecular imaging [53][54][55][56][57][58][59][60][61][62][63][64][65][66]. The advantages of QDs as biolabeling agents are (i) tunability of the emission wavelength by changing the particle size, (ii) a sharp and symmetrical emission peak, (iii) the high intensity and long lifetime of the fluorescence and (iv) a wide range of excitation wavelengths.…”

Section: Preparation Of Cds Quantum Dots By Co-precipitation In the Pmentioning

confidence: 99%

“…The preparation of PEGylated nanoparticles using acetal-PEG-b-PAMA can be applied to other materials such as inorganic porous nanoparticles [65], upconversion nanophosphors [66], fullerenes and so forth.…”

Section: Preparation Of Cds Quantum Dots By Co-precipitation In the Pmentioning

confidence: 99%

“…Thus, clays do not yet have practical pharmaceutical uses although some of their properties are clearly beneficial. Acetal-PEG-b-PAMA can help solve the above problem, as the coordination of the PEMA segment of the block copolymer on the surface improves the dispersion stability of clay particles [65].…”

Section: Porous Clay As a Drug Deliverymentioning

confidence: 99%

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Engineering of poly(ethylene glycol) chain-tethered surfaces to obtain high-performance bionanoparticles

Nagasaki

2010

Science and Technology of Advanced Materials

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A poly(ethylene glycol)-b-poly [2-(N,N-dimethylamino)ethyl methacrylate] block copolymer possessing a reactive acetal group at the end of the poly(ethylene glycol) (PEG) chain, that is, acetal-PEG-b-PAMA, was synthesized by a proprietary polymerization technique. Gold nanoparticles (GNPs) were prepared using the thus-synthesized acetal-PEG-b-PAMA block copolymer. The PEG-b-PAMA not only acted as a reducing agent of aurate ions but also attached to the nanoparticle surface. The GNPs obtained had controlled sizes and narrow size distributions. They also showed high dispersion stability owing to the presence of PEG tethering chains on the surface. The same strategy should also be applicable to the fabrication of semiconductor quantum dots and inorganic porous nanoparticles. The preparation of nanoparticles in situ, i.e. in the presence of acetal-PEG-b-PAMA, gave the most densely packed polymer layer on the nanoparticle surface; this was not observed when coating preformed nanoparticles. PEG/polyamine block copolymer was more functional on the metal surface than PEG/polyamine graft copolymer, as confirmed by angle-dependent x-ray photoelectron spectroscopy. We successfully solubilized the C 60 fullerene into aqueous media using acetal-PEG-b-PAMA. A C 60 /acetal-PEG-b-PAMA complex with a size below 5 nm was obtained by dialysis. The preparation and characterization of these materials are described in this review.

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Section: Preparation Of Cds Quantum Dots By Co-precipitation In the Pmentioning

confidence: 99%

Section: Preparation Of Cds Quantum Dots By Co-precipitation In the Pmentioning

confidence: 99%

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Engineering of poly(ethylene glycol) chain-tethered surfaces to obtain high-performance bionanoparticles

Nagasaki

2010

Science and Technology of Advanced Materials

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“…In addition, these materials have been shown to be non-toxic for trans-dermal application and oral administration [5,9]. Their swelling transition [10], on the other hand, suggests their potential as hosts of large molecules of pharmaceutical interest and their temperature controlled release.…”

Section: Introductionmentioning

confidence: 99%

Smectite as ciprofloxacin delivery system: Intercalation and temperature-controlled release properties

Rivera

Valdés

Jiménez

et al. 2016

Applied Clay Science

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Ciprofloxacin (Cipro) incorporation into Li-fluorhectorite (LiFh) clay and its temperaturecontrolled release. with potential pharmaceutical and biomedical applications.Structural characterization of the raw material and the clay-drug composites.Demonstration of the temperature-controlled drug release abilities of a colloidal suspension of the clay-drug composite, following pharmaceutical standards. AbstractClays have shown to be good candidates as drug delivery carriers. In the present paper, we use the temperature-dependent swelling of smectite clays to produce clay-drug composites with sizable drug load capacity. Specifically, we obtain a fluorohectorite-ciprofloxacin (Fh-Cipro) composite, in which a true intercalation of the drug between the clay interlayers has been verified by various experimental techniques. We evaluate the thermally activated drug release from a colloidal suspension of nanosized composite particles in water as well as in synthetic gastric juice from 37 0 C (body temperature) to 85 0 C. The temporal profiles of drug release from the clay fulfil the pharmaceutical standards for these systems. In this work, we have been able to produce a clay-based Temperature Controlled Release System (TCRS) with potential biomedical applications.

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“…It is used as an inactive substance for carrying the active ingredients of a medication and is also used as an active substance for pharmaceutical applications (Wang et al 2008). Several studies involving the use of MMT clay for drug delivery and drug release have been reported (Takahashi et al 2005;Rieux et al 2006;Bingfeg et al 2008;Wang et al 2008;Depan et al 2009). …”

Section: Introductionmentioning

confidence: 99%

Use of unnatural amino acids for design of novel organomodified clays as components of nanocomposite biomaterials

Katti

Ambre

Peterka

et al. 2010

Phil. Trans. R. Soc. A.

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Sodium montmorillonite (Na-MMT) clay was modified with three different unnatural amino acids in order to design intercalated clay structures that may be used for bone biomaterials applications. Prior work on polymer-clay nanocomposites (PCNs) has indicated the effect of the appropriate choice of modifiers on enhancing properties of PCNs. Our X-ray diffraction results indicate an increase in the d-spacing of Na-MMT clay after it was modified with the three unnatural amino acids. Transmission Fourier transform infrared spectroscopy experiments were carried out on the unmodified and modified MMT clay samples to study the molecular interactions between the amino acids used as modifiers and the Na-MMT clay. Cell culture experiments showed that the Na-MMT clay modified with the three amino acids was biocompatible as were the modified clay-incorporated films of chitosan/polygalacturonic acid/hydroxyapatite.

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Preparation of a novel PEG–clay hybrid as a DDS material: Dispersion stability and sustained release profiles

Cited by 123 publications

References 19 publications

Engineering of poly(ethylene glycol) chain-tethered surfaces to obtain high-performance bionanoparticles

Engineering of poly(ethylene glycol) chain-tethered surfaces to obtain high-performance bionanoparticles

Smectite as ciprofloxacin delivery system: Intercalation and temperature-controlled release properties

Use of unnatural amino acids for design of novel organomodified clays as components of nanocomposite biomaterials

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