Preparation of a novel floating ring capsule-type dosage form for stomach specific delivery

Mouzam, Md. Ismail; Dehghan, Mohamed Hassan; Asif, Shaikh Mohammed; Sahuji, Trupti; Chudiwal, Pooja

doi:10.1016/j.jsps.2011.01.004

Cited by 38 publications

(19 citation statements)

References 33 publications

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“…Drug release was performed using a USP type II apparatus at 75 rpm for 12 h. Aliquots of 5 ml were withdrawn at specified intervals of time, filtered and replenished with 5 ml fresh dissolution medium. Samples absorbance was measured at λ max 294 nm after suitable dilution [24]. The studies were performed in triplicate.…”

Section: In Vitro Drug Release Test and Modeling Of Drug Release Profmentioning

confidence: 99%

Formulation and Evaluation of Floating Matrix Tablets of Levofloxacin Hemihydrate Using Hydroxypropyl Methylcellulose K4m to Treat Helicobacter Pylori Infection

Baratam

2018

Asian J Pharm Clin Res

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Objective: The aim of the study was to develop a floating drug delivery system of levofloxacin (LVF) hemihydrate for sustained drug delivery to improve the extended retention in the stomach, oral bioavailability, and local site-specific action in the stomach. Methods: Preparation of LVF tablets using melt granulation method using hydroxypropyl methylcellulose (HPMC) K4M with sodium bicarbonate as gas generating agent. From LFTA1 to LFTA5, formulations were developed and evaluated for floating properties for swelling characteristics and in vitro drug release studies. In vitro dissolution was carried out using USP II paddle method using 0.1N HCI pH buffer at 50 rpm and samples were measured at 294 nm using ultraviolet-visible spectroscopy. Results: Obtained Fourier-transform infrared charts indicated that there is no positive evidence for the interaction between LVF and ingredients of the optimized formula. In vitro drug release was performed and drug release kinetics were evaluated using the linear regression method and were found to be followed the zero-order release by diffusion controlled release. Optimized formula was found to be LFTA4 with 20% of a polymer with 99.03% of drug release with 12 h of floating time and 32 s floating lag time. Conclusion: Matrix tablets (LFTA4) formulated employing 20% HPMC K4M are best suited to be used for gastroretentive dosage form of LVF.

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Section: In Vitro Drug Release Test and Modeling Of Drug Release Profmentioning

confidence: 99%

Formulation and Evaluation of Floating Matrix Tablets of Levofloxacin Hemihydrate Using Hydroxypropyl Methylcellulose K4m to Treat Helicobacter Pylori Infection

Baratam

2018

Asian J Pharm Clin Res

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“…Cellulose acetate phthalate, liquid paraffin and ethyl cellulose used as release modifiers and these releases the drug for the time period of 12 hours (Ali et al, 2006). Mouzam et al (2011) developed novel gloating ring cap delivery system in cross-linked by formaldehyde to hard gelatin capsule bearing Levofloxacin for the treatment of H. Pylori infection filled with Carbopol which is a hydrophilic polymer. This system exposed to acidic dissolution medium, a cap of gelatin capsule shell quickly dissolves and as a consequence, the formulation mixture gets exposed to the acidic environment only from a side.…”

Section: Figurementioning

confidence: 99%

Updates on Approaches to Increase the Residence Time of Drug in the Stomach for Site Specific Delivery: Brief Review

2018

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In the field of oral drug delivery system, a gastroretentive system is gaining popularity day by day. Numerous of research work and extensive literature are published in past few years on gastroretentive drug delivery system. It is the one of the best and appropriate approaches for increasing the residence time of drug in the stomach and diffuses drug slowly in the sustained manner which helps in the site-specific delivery of the drug as well also increases the bioavailability at site-specific of delivery. This helps in many challenges associated with conventional oral drug delivery system. Different ways are used for approaching gastroretention viz. swelling and expandable system, high-density system, magnetic system, bioadhesive system and buoyant system with or without gas generating agents. During data mining well in vitro characterization and in vivo characterization including gamma scintigraphic and MRI techniques are well established and reported. But, still, today in vivo characterization technique is major challenging for the researcher due to its limitation. The documented literature explains the use of animal models like beagle dogs, rabbits and human subjects for in vivo evaluation parameter but it leads to increase in variation that’s why this delivery system is limited in the market. This paper contains the latest literature compilation and various techniques used for gastroretention with its pros and cons. This review paper helps the researcher to take an overview of basics of gastroretentive drug delivery system and helps in understanding the basics of the system.Soni et al., International Current Pharmaceutical Journal, April 2018, 6(11): 81-91http://www.icpjonline.com/documents/Vol6Issue11/02.pdf

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“…The gel becomes buoyant by entrapping the gas bubbles and floats on the gastric contents as a viscous layer. Furthermore, cellulose ether polymers (HPMC) have a bulk density of less than unity in gastric fluids (132,133).…”

Section: Effect Of Polymer Type On Floating Behaviormentioning

confidence: 99%

Buoyancy-Generating Agents for Stomach-Specific Drug Delivery: An Overview with Special Emphasis on Floating Behavior

Ishak

2015

J Pharm Pharm Sci

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Gastric retentive drug delivery provides a promising technology exhibiting an extended gastric residence and a drug release independent of patient related variables. It is usually useful in improving local gastric treatment as well as overcoming drug-related problems .i.e. drugs having narrow absorption window, short half-life or low intestinal solubility. Buoyancy is considered one of the most promising approaches for gastro-retention of dosage forms. Floating drug delivery systems have a bulk density lower than gastric fluids and thus remain buoyant in the stomach causing an increase in gastric residence time. The buoyancy of these systems is attained by the aid of substances responsible to generate the low density. Various agents with different mechanisms were adopted either gas-generating agents, air entrapping swellable polymers, inherent low density substances, porous excipients, hollow/porous particles inducing preparation techniques or sublimating agents. Therefore, this review gives an exclusive descriptive classification of the different categories of these buoyancy-generating agents while representing the related research works. An overview is also conducted to describe relevant techniques assessing the floating behavior of such dosage forms either in vitro or in vivo. Finally, a collection representing FDA-approved floating pharmaceutical products is adopted with emphasis on the buoyancy-generating agent type used in each product. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.

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Preparation of a novel floating ring capsule-type dosage form for stomach specific delivery

Cited by 38 publications

References 33 publications

Formulation and Evaluation of Floating Matrix Tablets of Levofloxacin Hemihydrate Using Hydroxypropyl Methylcellulose K4m to Treat Helicobacter Pylori Infection

Formulation and Evaluation of Floating Matrix Tablets of Levofloxacin Hemihydrate Using Hydroxypropyl Methylcellulose K4m to Treat Helicobacter Pylori Infection

Updates on Approaches to Increase the Residence Time of Drug in the Stomach for Site Specific Delivery: Brief Review

Buoyancy-Generating Agents for Stomach-Specific Drug Delivery: An Overview with Special Emphasis on Floating Behavior

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