Preparation of a new molecularly imprinted polymer based on self‐crosslinkable cellulose acrylate in aqueous solution: A drug delivery system for furosemide

Abstract

In the present study, a new, green, and biodegradable molecularly imprinted polymer (MIP) based on modified cellulose is introduced for the drug furosemide. First, microcrystalline cellulose was converted into cellulose acrylate (CA). Then the prepared CA underwent self‐crosslinking in the drug preassembly solution. The preassembly solution of the drug was also prepared using furosemide as the template molecule and acrylamide as the functional monomer in an aqueous medium. The results obtained from the binding and selectivity studies indicate the successful preparation of the CA‐based MIP (CA‐MIP) in aqueous solution. In the final step, an in vitro release study of furosemide from the synthesized polymers was carried out in a pH = 7.41 phosphate‐buffered saline solution at 37 °C. The drug release profiles showed that the release rate of the CA‐MIP is more controlled than that of the corresponding nonimprinted polymer, especially at the early stages of release. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 45581.

Carboxymethyl cellulose-grafted graphene oxide for efficient antitumor drug delivery

“…So far, various types of polymers have been used in drug delivery studies [11,12], including synthetic polymers (polylactic acid, polyglycolide, polylactide-co-glycolide, polycyanoacrylate) and natural polymers (chitosan, gelatin, sodium alginate, etc.). Among the natural polymers, cellulose is much more preferred for modification and use because of its low cost, abundance, and intermolecular hydrogen bond patterns that form mechanically stable fibers [13]. Carboxymethyl cellulose (CMC), a common semisynthetic natural polymer derived from cellulose, shows promising applications for biological and biomedical engineering, including drug delivery [14][15][16], wound healing [17,18], bone tissue engineering [19,20], and biosensing [21].…”

Molecularly Imprinted Polymers (MIPs) in Sensors for Environmental and Biomedical Applications: A Review

“…MIPs have been fabricated for solid phase extraction [ 14 , 15 , 16 , 17 , 18 ], chromatographic separation [ 19 , 20 , 21 , 22 , 23 ], catalysis [ 24 , 25 , 26 , 27 , 28 ], drug delivery [ 29 , 30 , 31 , 32 , 33 ], study of the structure and function of proteins [ 34 , 35 , 36 , 37 , 38 ], environmental and biomedical sensing [ 39 , 40 , 41 , 42 , 43 ], water and wastewater treatment [ 44 , 45 , 46 , 47 , 48 ], and membrane-based separations [ 49 , 50 , 51 , 52 , 53 ]. MIP use for purification purposes is the most commercially available application, particularly in analytical chemistry; other uses are still in need of further development [ 54 ].…”

Synthesis of amino‐cosubstituted polyorganophosphazenes and fabrication of their nanoparticles for anticancer drug delivery

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