1979
DOI: 10.1073/pnas.76.3.1204
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Preparation of a disulfide-linked dimer of human placental lactogen fragment 1--134 with immunologic and biologic activity.

Abstract: In order to determine the chemical features of human placental lactogen (hPL) necessary for its biologic activity we prepared the following fragments from the plasmin-cleaved hormone: reduced and alkylated 1-134, reduced and alkylated , and a 1-134 dimer joined through the single cysteinyl residue at position 53. In a radioimmunoassa using antibodies against native hPL, the two reduced and a?1 kylated fragments produced nonparallel displacement and had less than 1% of the activity of hPL. The ability of redu… Show more

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Cited by 7 publications
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