Preparation of 99mTc-Nanocoll for use in sentinel node localization: Validation of a protocol for supplying in unit-dose syringes

Abstract

A capped 3 ml Plastipak syringe is a suitable container in which to supply 99mTc-Nanocoll. Neither passage through an R-Lock nor mixing with Patent Blue V affects the quality of 99mTc-Nanocoll.

Comparison of three magnetic nanoparticle tracers for sentinel lymph node biopsy in an in vivo porcine model

“…15,16 99m Tc nanocolloid has a mean particle size of approximately 8 nm, 17,18 while the particle size of the magnetic tracer used for the magnetic technique (Sienna+ ® , Endomagnetics Ltd, UK) is much larger with a mean size of approximately 60 nm. Because particle size is the most important property influencing lymphatic uptake and lymph node retention, 19 the identification of different SLNs by the two techniques could possibly arise due to differences in particle size of the radioisotope and magnetic tracer.…”

The washout rate of a subcutaneous 99mTc‐HSA depot in lower extremity lymphoedema

“…As Nanocoll Ò is colloids composed from HSA, an explanation to the noted difference in depot half-lives is the size exclusion theory: The size exclusion theory states that up to a certain size large molecules convect faster through the extracellular matrix than smaller molecules as long as other molecule characteristics such as shape, surface charge and hydrophobicity are similar (Reddy et al, 2006). The average size of Nanocoll Ò is 6-8 nm that is twice the size of HSA (OÕBrien et al, 2006;Jimenez et al, 2008). Diffusion is inversely related to molecular size and is a slow means of transportation over large distances.…”

“…The Einstein Stokes radius of HSA is 3,6 nm (Lindstrom et al, 1997). The average size of Nanocoll Ò is 6-8 nm that is twice the size of HSA (OÕBrien et al, 2006;Jimenez et al, 2008). According to the product information provided by the manufacturer, 95% of the colloids in Nanocoll Ò is under 80 nm in diameter, which means that the kit contains colloids with a wide range of different sizes.…”

“…, 1997). The average size of Nanocoll ® is 6–8 nm that is twice the size of HSA (O’Brien et al. , 2006; Jimenez et al.…”

Albumin Nanoparticle-Based Drug Delivery Systems

“… 10 Nano-sized albumin drug carrier emerged in 1970s 11 and 1980s, 12 whereas the latter one was developed into Nanocoll ® , [ 99 mTc]-labeled nanocolloidal albumin, approved for oncology rheumatology in 1995. 13 Some other albumin nanoformulations were developed during 1990s, including hydrocortisone-albumin, which was reported for treating eye inflammation, 14 and methotrexate–albumin conjugate, which was conducted in a Phase I trial for cancer treatment. 15 The latter one was reported capable of rheumatoid arthritis treatment in 2003.…”