Preparation of 99 mTc-MAG3: the effect on radiochemical purity of using sodium chloride injection from plastic ampoules that have been exposed to light

Abstract

Preparing 99m Tc-MAG3 using SCI from plastic ampoules that have been exposed to light causes reduced RCP. Exposure of plastic ampoules to light causes leaching of many compounds into the solution. An unknown leached compound destabilizes the 99m Tc-tartrate intermediate complex.

Preparation of 99mTc radiopharmaceuticals: the effect on radiochemical purity of using sodium chloride injection from plastic ampoules that have been exposed to light

“…It is possible that the effect of light might be different with ampoules from other manufacturers. This is illustrated by our previous work [1] in which we demonstrated that the effect on radiochemical purity was more pronounced with Steripak ampoules (Norton, Cheshire, UK).…”

“…In previous work on 99m Tc mertiatide, we demonstrated that when plastic ampoules containing sodium chloride injection are exposed to light, many contaminants are formed in the solution but we were unable to identify them or isolate which were responsible for the reduction in radiochemical purity [1]. This study shows that these contaminants also reduce the degree to which exametazime is labelled and slow the rate at which 99m Tc labels albumin nanocolloid and macrosalb.…”

“…Based on the finding that the radiochemical purity of 99m Tc mertiatide is reduced when it is prepared using sodium chloride injection from a plastic ampoule that has been exposed to light [1], it was decided to investigate whether the phenomenon affects any of the other 99m Tc radiopharmaceuticals prepared in the radiopharmacy. Ampoules were exposed for 7 days to provoke any effect on radiochemical purity.…”

“…Previous work undertaken in this radiopharmacy has shown that the radiochemical purity of technetium-99m ( 99m Tc) mertiatide injection is reduced when sodium chloride injection from a plastic ampoule that has been exposed to light is used in its preparation [1]. Whether or not this phenomenon affects other 99m Tc radiopharmaceuticals is unknown but would be valuable information to ensure that products of the highest quality are prepared for administration to patients.…”

Pitfalls and Limitations of SPECT, PET, and Therapeutic Radiopharmaceuticals

“…It has been noted that saline ampoules exposed to light can adversely affect the formation of the desired complex; curiously, this appears to affect the formation of 99m Tc tartrate rather than the transchelation step. 33 It has also been reported that the duration of the boiling step is critical. 34 There was a report that suggested that the quality of sestamibi kits had declined over the years, as evidenced by deterioration in the quality of dual-phase parathyroid scintigraphic studies.…”