Preparation of 90YCl3 radiopharmaceutical precursor for nuclear medicine using technology of centrifugal extractors

Short life fission products extracted from molten salt reactor fuel for radiopharmaceutical applications.

“…90 Y as daughter product of 90 Sr must be intensively separated. A number of methods have been applied worldwide to separate carrier-free 90 Y from 90 Sr to clinical standards, including centrifugal extraction, see Srank, et al (2010) [52], electrochemical separation, as reported by Chakravarty, et al (2008) [53], supported liquid membrane (Kandwal, 2011) [54], precipitation (Chakravarty, et al 2019) [55], and various forms of chromatography, see Hsieh, et al (1993) [56] and Malja (2000) [57], amongst others. 90 Y is used in various forms in radiotherapy and imaging.…”

Pivotal role of separation chemistry in the development of radionuclide generators to meet clinical demands

“…100 This work was further extended by Srank et al to obtain multicurie levels of 90 Y with very high radionuclidic purity. 101 The extraction of 90 Y from 90 Sr using crown ethers has also been extensively studied, but with limited success. 102,103 Other solvent extraction approaches reported for the isolation of 90 Y from 90 Sr were based on the use of a water-nitrobenzene extraction system, sodium dicarbolyl cobaltate, and dicarbolylcobaltate (HDCC)-benzo-crown-5.…”

“…158,159 Another notable development in this direction is the use of centrifugal extractors to separate 90 Y from an equilibrium mixture of 90 Sr/ 90 Y. 101 The benecial use of nanomaterials in column chromatography separation approaches, in the thermochromatography method, in electrochemical separation strategies, and in the MSIG concept discussed in this article should inspire the nuclear medicine community, as they present innovative separation approaches for the design of next generation radionuclide generators. The implementation of such separation strategies, along with automation in centralized radiopharmacies, seems to be an effective proposition; although, such approaches will require the availability of qualied skilled manpower to perform the separations.…”

On the Separation of Yttrium-90 from High-Level Liquid Waste: Purification to Clinical-Grade Radiochemical Precursor, Clinical Translation in Formulation of90Y-DOTATATE Patient Dose

“…4 Toward this, several methods have been adopted worldwide for development of generators to separate the 90 Y daughter from its long-lived parent 90 Sr, with which it remains in secular equilibrium. Such generators, which aim at separation of the daughter 90 Y in purity, equivalent to clinical standards, are based on electrochemical separation, 5 precipitation, 6 extraction, 7 ion exchange chromatography 8,9 supported liquid membrane (SLM) separation 10 etc.…”