Preparation of 3D Print Scaffolds Fe3O4@ Food Oils/Chitosan/Polylactic Acid/Polyurethane Modified Natural Protein Pegylated for Cardiovascular Blood

Abstract

Food oils used in 3D polysaccharides modified with natural protein polymer modified polymer scaffolds can help to reduce blood pressure. This study aimed to use food oils as blood pressure-reducing medicine, bind them to magnetic iron nanoparticles, then bind them to polymeric 3D scaffolds (chitosan, polylactic acid and polyurethane), modified with natural protein and finally separate them. This method made it possible to investigate different variables for nanoparticles. In this project, synthesis polymer, food medicinal oils, modified gelatin, PEGylation, food loading and release process in nanocarrier with different concentrations were examined and cell proliferation was optimized. The results show that 75% of the medicine loaded on iron magnetic NPs containing PEGylated polymer scaffolds was released. Cell proliferation was performed for the sample. In this process, modification of scaffolding with polysaccharides modified with natural protein and food oil increased the efficiency of nanoparticles among the studied Allium sativum oil and Zingiber officinale oils. These behaved very similarly to each other and A. sativum had the biggest effect in lowering blood pressure. The application of food medicine oils in 3D mode scaffolding has not been studied before and this is the first analysis to do so, using nanoparticles.

Advancing biomedicine with gel‐based materials and composites: A comprehensive review

“…Also, polylactic acid and polyurethane are biocompatible polymer gels used in cardiac repair. However, they possess a long degradation time 27 . Therefore, polycaprolactone scaffolds with multi‐walled CNTs are used for cardiac regeneration 28 …”

“…However, they possess a long degradation time. 27 Therefore, polycaprolactone scaffolds with multi-walled CNTs are used for cardiac regeneration. 28…”