Preparation of 3D cubic ordered mesoporous bioactive glasses

Yun, Hui-suk; Kim, Seung-eon; Hyun, Yong-Taek

doi:10.1016/j.solidstatesciences.2007.11.037

Cited by 34 publications

(32 citation statements)

References 35 publications

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“…The three spectra only showed one resonance that corresponded to the q 0 environment, thus indicating that calcium orthophosphate is formed before the subsequent thermal treatment (see Figure S3 in the Supporting Information), without the presence of other polyphosphate species. 29 Si NMR. 29 Si NMR spectroscopy was used to evaluate the network connectivity of MBGs as a function of chemical composition.…”

Section: Methodsmentioning

confidence: 99%

Essential Role of Calcium Phosphate Heterogeneities in 2D-Hexagonal and 3D-Cubic SiO₂−CaO−P₂O₅ Mesoporous Bioactive Glasses

et al. 2009

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Mesoporous bioactive glasses (MBGs) with a compoisition of 85SiO 2 -10CaO-5P 2 O 5 (mol %) have been prepared through the evaporation-induced self-assembly (EISA) method, using P123 as a structure directing agent. For the first time, SiO 2 -CaO-P 2 O 5 MBGs with identical composition and textural properties, but exhibiting different bicontinuous 3D-cubic and 2D-hexagonal structures, have been prepared. These materials allow us to discriminate the role of the structure on the bioactivity, from other parameters. To understand the role of each component on the mesostructure, local environment, and bioactive behavior, mesoporous 100SiO 2 , 95SiO 2 -5P 2 O 5 , and 90SiO 2 -10CaO (mol %) materials were also prepared under the same conditions. The results demonstrate that the joint presence of CaO and P 2 O 5 results in amorphous calcium phosphate (ACP) clusters sited at the pore wall surface. This heterogeneity highly improves the bioactive behavior of these materials. In addition, the presence of ACP clusters within the silica network leads to different mesoporous structures. The mesoporous order can be tuned through a rigorous control of the solvent evaporation temperature during the mesophase formation, resulting in p6mm, p6mm/Ia3d coexistence, and Ia3d phases for 20, 30, and 40°C, respectively. Preliminary results indicate that, in the case of identical composition and textural properties, the mesoporous structure does not have influence on the apatite formation, although initial ionic exchange is slightly enhanced for 3D cubic bicontinuous structures.

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Section: Methodsmentioning

confidence: 99%

Essential Role of Calcium Phosphate Heterogeneities in 2D-Hexagonal and 3D-Cubic SiO₂−CaO−P₂O₅ Mesoporous Bioactive Glasses

et al. 2009

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“…32 In a typical synthesis, 2.88 g of F127 is dissolved in 18.1 mL of EtOH. Stock solutions, which were prepared by mixing 1.36 g of calcium nitrate tetrahydrate, 0.26 mL of triethyl phosphate, 6 mL of tetraethyl orthosilicate, 0.95 mL of HCl (1 M), 7.62 mL of ethyl alcohol, and 2.86 mL of H 2 O, were added to this solution after stirring them for 1 hour separately and were vigorously stirred together for another 4 hours at 40°C.…”

Section: Materials and Methods Synthesis Of Mbg And Preparation Of Gementioning

confidence: 99%

Biomimetic component coating on 3D scaffolds using high bioactivity of mesoporous bioactive ceramics

Yun¹,

Khang²,

Choi³

2011

IJN

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Background Mesoporous bioactive glasses (MBGs) are very attractive materials for use in bone tissue regeneration because of their extraordinarily high bone-forming bioactivity in vitro. That is, MBGs may induce the rapid formation of hydroxy apatite (HA) in simulated body fluid (SBF), which is a major inorganic component of bone extracellular matrix (ECM) and comes with both good osteoconductivity and high affinity to adsorb proteins. Meanwhile, the high bioactivity of MBGs may lead to an abrupt initial local pH variation during the initial Ca ion-leaching from MBGs at the initial transplant stage, which may induce unexpected negative effects on using them in in vivo application. In this study we suggest a new way of using MBGs in bone tissue regeneration that can improve the strength and make up for the weakness of MBGs. We applied the outstanding bone-forming bioactivity of MBG to coat the main ECM components HA and collagen on the MBG-polycarplolactone (PCL) composite scaffolds for improving their function as bone scaffolds in tissue regeneration. This precoating process can also expect to reduce initial local pH variation of MBGs. Methods and materials The MBG-PCL scaffolds were immersed in the mixed solution of the collagen and SBF at 37°C for 24 hours. The coating of ECM components on the MBG-PCL scaffolds and the effect of ECM coating on in vitro cell behaviors were confirmed. Results The ECM components were fully coated on MBG-PCL scaffolds after immersing in SBF containing dilute collagen-I solution only for 24 hours due to the high bone-forming bioactivity of MBG. Both cell affinity and osteoconductivity of MBG-PCL scaffolds were dramatically enhanced by this precoating process. Conclusion The precoating process of ECM components on MBG-PCL scaffold using a high bioactivity of MBG was not only effective in enhancing the functionality of scaffolds but also effective in eliminating the unexpected side effect. The MBG-PCL scaffold-coated ECM components ideally satisfied the required conditions of scaffold in tissue engineering, including 3D well-interconnected pore structures with high porosity, good bioactivity, enhanced cell affinity, biocompatibility, osteoconductivity, and sufficient mechanical properties, and promise excellent potential application in the field of biomaterials.

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“…The TG profile shows a mass loss of 26.6% which occurs in three stages. The first endothermic peak (23-275°C) is assigned to desorption of water (physical or chemical) and residual ethanol, the second exothermic peak (310-410°C) can be attributed to the removal of F127 surfactant, while the third sharp exothermic peak at 460°C in the DTA curve might be due to complete decomposition of F127 coordinated to inorganic precursors [25]. In addition, since the TG curves showed that the weight loss ended at 460°C, the calcination temperature above this value is sufficient for complete removal of the organic surfactant molecules.…”

Section: Characterization Of Catalystmentioning

confidence: 99%

Direct synthesis of Ti-containing SBA-16-type mesoporous material by the evaporation-induced self-assembly method and its catalytic performance for oxidative desulfurization

Shah

Abdalla

2009

Journal of Colloid and Interface Science

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Preparation of 3D cubic ordered mesoporous bioactive glasses

Cited by 34 publications

References 35 publications

Essential Role of Calcium Phosphate Heterogeneities in 2D-Hexagonal and 3D-Cubic SiO₂−CaO−P₂O₅ Mesoporous Bioactive Glasses

Essential Role of Calcium Phosphate Heterogeneities in 2D-Hexagonal and 3D-Cubic SiO₂−CaO−P₂O₅ Mesoporous Bioactive Glasses

Biomimetic component coating on 3D scaffolds using high bioactivity of mesoporous bioactive ceramics

Direct synthesis of Ti-containing SBA-16-type mesoporous material by the evaporation-induced self-assembly method and its catalytic performance for oxidative desulfurization

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Preparation of 3D cubic ordered mesoporous bioactive glasses

Cited by 34 publications

References 35 publications

Essential Role of Calcium Phosphate Heterogeneities in 2D-Hexagonal and 3D-Cubic SiO2−CaO−P2O5 Mesoporous Bioactive Glasses

Essential Role of Calcium Phosphate Heterogeneities in 2D-Hexagonal and 3D-Cubic SiO2−CaO−P2O5 Mesoporous Bioactive Glasses

Biomimetic component coating on 3D scaffolds using high bioactivity of mesoporous bioactive ceramics

Direct synthesis of Ti-containing SBA-16-type mesoporous material by the evaporation-induced self-assembly method and its catalytic performance for oxidative desulfurization

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Essential Role of Calcium Phosphate Heterogeneities in 2D-Hexagonal and 3D-Cubic SiO₂−CaO−P₂O₅ Mesoporous Bioactive Glasses

Essential Role of Calcium Phosphate Heterogeneities in 2D-Hexagonal and 3D-Cubic SiO₂−CaO−P₂O₅ Mesoporous Bioactive Glasses