Preparation of 227Ac/223Ra by neutron irradiation of 226Ra

Abstract

Radium-223 is a prospective alpha-emitter for targeted radionuclide therapy. Although 223 Ra is formed naturally by the decay of 235 U, for practical reasons its preparation involves neutron irradiation of 226 Ra. The b -

Study of223Ra uptake mechanism on hydroxyapatite and titanium dioxide nanoparticles as a function of pH

“…Possible elds and ways of its applications could be signicantly wider due to the capture of recoil nuclei by the nanoparticles and advantages of 223 Ra. Furthermore, 223 Ra can be obtained from a radionuclide generator 227 Ac/ 227 Th/ 223 Ra, [28][29][30][31][32][33] which can probably guarantee availability of the radionuclide in the hospitals. Main introduced disadvantage of 223 Ra are recoil nuclei appearing during the radioactive decay.…”

Surface protolytic property characterization of hydroxyapatite and titanium dioxide nanoparticles

“…[23][24][25][26][27][28] Our aim was to determine nanomaterial properties including the parameters characterizing the protonation and ion-exchange processes taking place on the surface of nHAp and nTiO 2 for further 223 Ra sorption studies, as a nanoparticle radionuclide carrier for nuclear medicine. [29][30][31][32] Due to modeling of the new material surface sorption processes, separate experiments should be performed in order to obtain credible input surface protolysis and site density data.…”

Overview of the Most Promising Radionuclides for Targeted Alpha Therapy: The “Hopeful Eight”

“…Another possibility is from 227 Ac decay, which substantially improved 223 Ra availability especially through the development of 227 Ac- 227 Th- 223 Ra generator. The 227 Ac necessary for this procedure is mainly produced by thermal neutron irradiation of 226 Ra targets following the 226 Ra (n,γ) 227 Ra— 227 Ac reaction (in nuclear reactor) [ 226 , 227 ] or to a lesser extent by proton irradiation of natural 232 Th targets. For this latter method, a 10-day irradiation using an intense proton beam of 800 MeV demonstrated the possibility to generate 227 Ac through the 232 Th (p,x) 227 Ac reaction.…”