Preparation of [18F]β-CFT-FP and [11C]β-CFT-FP, selective radioligands for visualisation of the dopamine transporter using positron emission tomography (PET)

Potential of [18F]β‐CFT‐FE (2β‐carbomethoxy‐3β‐(4‐fluorophenyl)‐8‐(2‐[18F]fluoroethyl)nortropane) as a dopamine transporter ligand: A PET study in the conscious monkey brain

“…␤-CFT-FE was synthesized according to the reported procedure (Kämärä inen et al, 2000) with slight modifications. To a solution of nor-␤-CFT (159 mg, 0.6 mmol), triethylamine (0.13 mL, 0.9 mmol) and sodium iodide (catalytic amount) in DMSO (3 mL), 1-bromo-2fluoroethane (0.18 mL, 2.4 mmol) was added.…”

Fluorine-18 labeling of three novel d-peptides by conjugation with N-succinimidyl-4-[18F]fluorobenzoate and preliminary examination by postmortem whole-hemisphere human brain autoradiography

“…prosthetic group, with a second molecule. Important procedures via prosthetic groups include: 132 . In this thesis, in paper I, [ 18 F]fluoroethyl was used as prosthetic group to radiolabel the hydroxyl group so that we could use same precursor for both 11 C and 18 F radiolabelling.…”

Fluorine-18 Radiolabeled PET Tracers for Imaging Monoamine Transporters: Dopamine, Serotonin, and Norepinephrine

“…In an effort to reduce the time required to reach peak uptake of [ 18 F] 8 , the N -[ 18 F]fluoroethyl[105] and N -[ 18 F]fluoropropyl[109,110] derivatives, [ 18 F] 13 and [ 18 F] 14 , respectively, were prepared. In vitro binding assays demonstrated that both 13 and 14 had a reduced affinity for the DAT, SERT, and NET relative to 8 , but 13 and 14 both had a slightly improved selectivity for the DAT over the SERT relative to 8 .…”