As the demand for ready-made food is increasing, it is necessary to develop effective food packaging materials with antimicrobial activity to ensure microbiological safety of food. In this study, SnO 2 nanoparticles (SnO 2 NPs) are prepared with chemical precipitation method. Different amounts of SnO 2 NP S (1, 3, 5, 7, and 10 wt%) are reinforced into the poly(butylene adipate-coterephthalate) (PBAT) using ultrasonication method, and the nanocomposites are made using solvent casting method. The structural properties of nanocomposites have been analyzed with FT-IR, XRD, SEM, and TEM. The investigation on structural properties is confirming the strong attraction between the SnO 2 and the PBAT. Mechanical tests like elongation at break and tensile strength have been investigated, and our results show the enhancement in mechanical strength of nanocomposites over pure PBAT. This is due to uniform dispersion of SnO 2 NPs in the PBAT matrix and strong interaction between the carbonyl group of PBAT and oxygen atom of SnO 2 . Oxygen and water permeability of PBAT/SnO 2 showed that the nanocomposites had better barrier properties than the PBAT. In addition, the PBAT/SnO 2 (PSO-10) nanocomposites exhibited profound antibacterial activity against the food-borne pathogens E.coli and S. aureus. Therefore, PBAT/SnO 2 nanocomposites can be used for food packaging applications as it shows a good mechanical, thermal, degradation, barrier, and antimicrobial activities.