Preparation, material properties and antimicrobial efficacy of silicone hydrogel by modulating silicone and hydrophilic monomer

Chien, Hsiu‐Wen; Kuo, Chun-Chao

doi:10.1080/09205063.2019.1620593

Cited by 15 publications

(12 citation statements)

References 43 publications

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“…The pHEMA/LEV series showed a higher WCA than the pHEMA control, while still much lower than 90°, which was indicative of the hydrophobicity that is often considered to be a dominant factor in protein adsorption [ 44 ]. The zwitterionic sulfobetaine unit on PSBMA can interact with water via electrostatic forces and hydrogen bonds, which provides a strong water affinity [ 45 ]; meanwhile, the porous network of hydrogels also facilitates the retention of large amounts of water. Thus, the incorporation of drug-loaded PSBMA nanogels did not adversely affect the hydrophilicity of contact lenses, suggesting their suitability as a potential material for contact lenses.…”

Section: Resultsmentioning

confidence: 99%

“…The elongation at break of the hydrogels decreased from 320% to 180%, and the breaking strength decreased from 3.53 MPa to 2.18 MPa. The Young’s moduli calculated based on the slope of the initial linear region in the stress−strain curves for the prepared five sets of contact lenses were in the range of 0.98~1.43 MPa [ 11 , 45 ]. It has been reported that the Young’s modulus of commercial pHEMA-based soft contact lenses is usually in the range from 0.37 to 1.63 MPa.…”

Section: Resultsmentioning

confidence: 99%

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Novel Contact Lenses Embedded with Drug-Loaded Zwitterionic Nanogels for Extended Ophthalmic Drug Delivery

Wang

Zhang

et al. 2021

Nanomaterials

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Therapeutic ophthalmic contact lenses with prolonged drug release and improved bioavailability have been developed to circumvent tedious eye drop instillation. In this work, zwitterionic nanogels based on poly(sulfobetaine methacrylate) (PSBMA) were easily fabricated by one-step reflux-precipitation polymerization, with the advantages of being surfactant-free and morphology controlled. Then, the ophthalmic drug levofloxacin (LEV) was encapsulated into the nanogels. A set of contact lenses with varied nanogel-loading content was fabricated by the cast molding method, with the drug-loaded nanogels dispersed in pre-monomer solutions composed of 2-hydroxyethyl methacrylate (HEMA) and N-vinyl-2-pyrrolidone (NVP). The structure, surface morphology, water contact angle (WCA), equilibrium water content (EWC), transmittance, and mechanical properties of the contact lenses were subsequently investigated, and in vitro drug release and biocompatibility were further evaluated. As a result, the optimized contact lens with nanogel-loading content of 8 wt% could sustainably deliver LEV for ten days, with critical lens properties within the range of recommended values for commercial contact lenses. Moreover, cell viability assays revealed that the prepared contact lenses were cytocompatible, suggesting their significant potential as an alternative to traditional eye drops or ointment formulations for long-term oculopathy treatment.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Novel Contact Lenses Embedded with Drug-Loaded Zwitterionic Nanogels for Extended Ophthalmic Drug Delivery

Wang

Zhang

et al. 2021

Nanomaterials

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“…However, two studies have examined whether changing the oxygen permeability of contact lens polymers might, albeit perhaps serendipitously, alter bacterial adhesion. A series of SiHy lens polymers was produced where the silicone monomer to HEMA ratio or the DMA:HEMA ratio was altered [47]. Changes to the silicone monomer to HEMA ratio did not alter the adhesion of Staphylococcus aureus to the materials, whereas increasing the ratio of DMA did decrease bacterial adhesion [47], and this was related to increases in the water content of the lenses.…”

Section: Adhesion Of Microbesmentioning

confidence: 99%

BCLA CLEAR - Contact lens wettability, cleaning, disinfection and interactions with tears

Willcox

Keir

Maseedupally

et al. 2021

Contact Lens and Anterior Eye

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Contact lens materials have undergone significant changes over the past 20 years, particularly with respect to the introduction of silicone hydrogel materials. Whilst this development addressed hypoxic issues, other important areas relating to contact lens success, notably comfort, require further research.Contact lens wettability remains a crucially important part of biocompatibility. Contact lenses can be made more wettable by incorporation of surfactants into blister packs, internal wetting agents, surface treatments or care solutions. However, there remains no clear association between contact lens wettability and comfort, making it challenging to determine the potential for these approaches to be of significant clinical benefit. Most contact lenses are used on a daily wear, reusable basis, which requires them to be disinfected when not worn. The ideal disinfecting solution would also improve comfort during wear. However, balancing these requirements with other factors, including biocompatibility, remains a challenge. Soft lens materials invariably take up and subsequently release certain components of disinfecting solutions onto the ocular surface. This may affect tear film stability and the normal ocular microbiome, and further research is needed in this area to determine whether this has any affect on comfort. Finally, contact lens materials sorb components of the tear film, and these interactions are complex and may change the biochemistry of the tear film, which in turn may affect their comfort.In conclusion, the interaction between lens materials, tear film and disinfection solution plays an important role in the biocompatibility of lenses. However, the exact role and whether this can be altered to improve biocompatibility and comfort during wear remains debatable. This report summarises the best available evidence to examine this complex relationship and the opportunities for practitioners to enhance in-eye comfort of contemporary lenses, along with providing suggestions for areas of study that may provide further information on this topic.

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“…The water uptake (Table 2 and Figure S3) was higher for silicone hydrogels than for HEMA hydrogels despite the hydrophobic character of TRIS. The addition of hydrophilic monomers, mainly NVP [50,51] and, to a lesser extent, MPC [17], explains the greater water uptake of silicone hydrogels. In fact, the designed silicone hydrogels showed a higher water content than that previously recorded for other silicone hydrogels [48,50], even with a very similar composition [52].…”

Section: Water Uptake and Wettabilitymentioning

confidence: 99%

Resveratrol-Loaded Hydrogel Contact Lenses with Antioxidant and Antibiofilm Performance

et al. 2021

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Contact lenses (CLs) are prone to biofilm formation, which may cause severe ocular infections. Since the use of antibiotics is associated with resistance concerns, here, two alternative strategies were evaluated to endow CLs with antibiofilm features: copolymerization with the antifouling monomer 2-methacryloyloxyethyl phosphorylcholine (MPC) and loading of the antioxidant resveratrol with known antibacterial activity. MPC has, so far, been used to increase water retention on the CL surface (Proclear® 1 day CLs). Both poly(hydroxyethyl methacrylate) (HEMA) and silicone hydrogels were prepared with MPC covering a wide range of concentrations (from 0 to 101 mM). All hydrogels showed physical properties adequate for CLs and successfully passed the hen's egg-chorioallantoic membrane (HET-CAM) test. Silicone hydrogels had stronger affinity for resveratrol, with higher loading and a slower release rate. Ex vivo cornea and sclera permeability tests revealed that resveratrol released from the hydrogels readily accumulated in both tissues but did not cross through. The antibiofilm tests against Pseudomonas aeruginosa and Staphylococcus aureus evidenced that, in general, resveratrol decreased biofilm formation, which correlated with its concentration-dependent antibacterial capability. Preferential adsorption of lysozyme, compared to albumin, might also contribute to the antimicrobial activity. In addition, importantly, the loading of resveratrol in the hydrogels preserved the antioxidant activity, even against photodegradation. Overall, the designed hydrogels can host therapeutically relevant amounts of resveratrol to be sustainedly released on the eye, providing antibiofilm and antioxidant performance.

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Preparation, material properties and antimicrobial efficacy of silicone hydrogel by modulating silicone and hydrophilic monomer

Cited by 15 publications

References 43 publications

Novel Contact Lenses Embedded with Drug-Loaded Zwitterionic Nanogels for Extended Ophthalmic Drug Delivery

Novel Contact Lenses Embedded with Drug-Loaded Zwitterionic Nanogels for Extended Ophthalmic Drug Delivery

BCLA CLEAR - Contact lens wettability, cleaning, disinfection and interactions with tears

Resveratrol-Loaded Hydrogel Contact Lenses with Antioxidant and Antibiofilm Performance

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