Preparation, Investigation and Study of Biological Applications of Tyrosine Derivatives against Breast Cancer Cells

Abstract

Cancerous tumors are considered a serious and fatal diseases for both sexes and for all ages, even fetuses before their birth. Therefore, it has become necessary to find an alternative treatment for radiation to be safer and less dangerous than chemical treatments. Therefore, derivatives of one of the amino acids, such as tyrosine, were prepared. Tyrosine or tyrosine is one of the well-known and important amino acids for humans, and it is present in most proteins; The human body uses it to produce several types of hormones such as noradrenaline and adrenaline. In this paper, we prepared new derivatives of tyrosine represented by (four, five, six)-membered ring, then all these new tyrosine derivatives investigated by several techniques (FT.IR, H.NMR)–spectrophotometric, other physical and chemical properties, with assaying for some new created derivatives as anti-cancer.

Review on Applications of Dendrimer-Chemical Compounds in Pharmaceutical and Industrial Fields

“…However, carbon nanotubes have caused damage at lower levels. As for copper oxide, it was found to be the worst harmful, in addition to that it was the only nanomaterial known by researchers to have clear health risks [21][22][23][24][25].…”

"Creation of Innovated Macrocyclic Sulfazan-Formazan Compounds and Linear Sulfazan-Formazan for the first Time Globally with their Assay as Antifungal"

“…They were considered among the organic compounds of importance in organic chemistry because they contain two highly effective groups in several fields of chemistry, especially in coordination chemistry, as a ligands because they contain doublets. Free electrons and donor atoms to coordinate with ions to form complexes [23][24][25][26][27][28]. Formazan also enter many anti-bacterial [29][30][31][32][33] and anti-fungal compounds [34][35][36][37] and types of cancer [38,39], especially breast and laryngeal cancers, as anti-bacterial and anti-fungal, and other studies [40,41].…”

"Inventing of Macrocyclic Formazan Compounds with Their Evaluation in Nano- Behavior in the Scanning Microscope and Chromatography"

“…And because their studies and references are a few for this cause the researcher Dr. Nagham Aljamali prepared and carried out various compounds from Macrocyclic-Formazan by using various conditions and different basic medium [3][4][5][6][7] like (Pyridine ,Pipridine ,5 % Sodium hydroxide, Triethyl amine,…) [3], and linked them with heterocyclic compounds and other compounds with more than two hetero atoms to increase their effectiveness [7][8][9][10][11] , biological [13,16] and industrial applications [17,20]. Cyclic Formazan has cyclic structure of (-N=N=C-N-in cyclic structure) or (-N=N-C-N-NH-in cyclic structure) according to type of amine in reaction [1,2]., They were considered among the organic compounds of importance in organic chemistry because they contain two highly effective groups in several fields of chemistry [1,[21][22][23][24], especially in coordination chemistry [25][26][27], as a ligands because they contain free electrons of donor atoms to coordinate with ions to form complexes [28][29][30]. Formazan also tested in many studies as anti-bacterial [31][32][33][34] and anti-fungal compounds [35][36] and types of cancer [37][38][39], especially breast [40] and laryngeal cancers [41], as anti-bacterial…”