Preparation, characterization, and Staphylococcus aureus biofilm elimination effect of baicalein-loaded tyrosine/hyaluronic acid/β-cyclodextrin-grafted chitosan nano-delivery system

Tang, Ling; Zhang, Zhongbin; Ding, Wenyou; Tang, Jing; Deng, Xiuzhen; He, Qiumei; Kong, Xiangyu; Chen, Jinqing; Truong, Thi Minh Hien; Wang, Gang; Zhu, Xiaoyong; Ding, Wenya

doi:10.1016/j.ijbiomac.2023.128066

Cited by 5 publications

(2 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, the dense negative charges can undergo strong repulsive interactions to avoid the nonspecific adsorption between the HA-modified nanocarriers and negatively charged serum in the blood, which can extend the plasma half-life of the nanocarriers and enhance the HA delivery efficiency and therapeutic effects. Notably, the steric hindrance and high electrostatic properties of HA can effectively enhance the stability of nanoparticles …”

Section: Introductionmentioning

confidence: 99%

“…Notably, the steric hindrance and high electrostatic properties of HA can effectively enhance the stability of nanoparticles. 20 Lutein (Lut) is a kind of lipophilic natural carotenoids with excellent antioxidation, anti-inflammatory, and anticancer effects. 21−23 However, Lut's extremely low water solubility, chemical instability, and poor bioavailability have severely restricted its application in the food industries.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

pH-Driven Self-Assembly of Functional Lysozyme–Hyaluronan Complex Colloidal Nanoparticles for the Oral Delivery of Lutein

Liu,

Li,

Lian

et al. 2024

Crystal Growth & Design

View full text Add to dashboard Cite

Despite its various health-promoting bioactivities, poor water solubility, chemical instability, and low bioavailability of lutein have limited its further application in the food industry. This paper reports a simple and a green pH-driven method to synthesize lutein-loaded lysozyme−hyaluronan complex colloidal nanoparticles (Lut@LYS-HANPs) able to overcome the aforementioned shortcomings. The fabricated Lut@LYS-HANPs exhibited a stabilized particle size (164 nm), negative surface zetapotential (−44.86 mV), excellent long-term storage stability, and favorable redispersibility. The encapsulation efficiency and loading ability of lutein in the prepared Lut@LYS-HANPs were 96.23 and 11.07%, respectively. Infrared spectra demonstrated that the dominant interaction forces behind the formed Lut@LYS-HANPs were hydrogen bonds and hydrophobic and electrostatic interactions. The circular dichroism spectra indicated that lutein incorporation mainly changed the α-helix and β-sheet contents of lysozyme. Besides, the

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%