Preparation, characterization, and properties of polylactide (PLA)–poly(ethylene glycol) (PEG) copolymers: A potential drug carrier

Abstract

SynopsisPolylactide (PLA)-poly(ethy1ene glycol) (PEG) copolymers were synthesized from polyethylene glycol and D,L-lactide using low toxic stannous octoate as catalyst at 180°C by bulk polymerization. The copolymers were characterized by GPC, IR, and 13C-NMR. A full assignment NMR spectrum is presented. The physical, drug release, and biodegradable properties in oib-o of PLA-PEG copolymers were investigated. The result indicates that the rates of drug release and biodegradation could be tailored by adjusting polymer composition. This amorphous material might be used as a drug carrier in medical applications.

Synthesis of three-arm block copolymer poly(lactic-<em>co</em>-glycolic acid)&ndash;poly(ethylene glycol) with oxalyl chloride and its application in hydrophobic drug delivery

“…All kinds of aliphatic polyesters, such as poly(l-lactic acid) (PLA), 14,15 poly(ε-caprolactone), 13,16 and poly(lacticco-glycolic acid) (PLGA), 17 have been linked with a hydrophilic polyethylene glycol (PEG) segment to yield the amphiphilic copolymer structure. 18 In 1994, the effect on pharmacokinetics of PLGA microparticles externally coated with PEG was first described.…”

Natural Products: A Minefield of Biomaterials

“…Biodegradable polymers such as poly (lactic acid), poly (glycolic acid), and their respective copolymers have been used in several drug delivery systems. However, few attempts have been make to use starch-based polymers in these types of applications; despite being well known that they are biodegradable materials; they have been proposed in several works to be used as biomaterials [130][131][132][133].…”

Influence of Temperature on the Conformational Guided Physical Properties of Ultrathin Films of PLLA

“…Among the family of environmental friendly biodegradable polymers, poly (L lactic acid), PLLA (-[CH 2 CH(CH 3 )COO] n -) -has been attracting much attention because of many advantages in its intrinsic properties. For example, the polymer exhibits biocompatibility [1][2][3] , and so has importance in medical industry for applications such as drug delivery systems, implant materials for bone fixation 4 , nuclear oncology and surgical suture [5][6][7][8][9][10][11][12][13][14][15] . But the main reason behind its debut in large-scale production is found in its tremendous potential in traditional applications where thermoplastics are employed, such as the production of disposable products for the packaging and film industries 16 .…”