Preparation, characterization and in vivo observation of phospholipid-based gas-filled microbubbles containing hirudin

Zhao, Ying-Zheng; Liang, Haidong; Mei, Xingguo; Halliwell, Michael

doi:10.1016/j.ultrasmedbio.2005.05.007

Cited by 41 publications

(26 citation statements)

References 24 publications

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“…The agent was not sized before sonication, so it is not possible to determine the effects of sonication on the agent. Zhao et al (2005) developed an in-house lipid-based agent and used only gentle shaking to form the emulsion-like contrast agent. No aggregation or fusion of the lipid microbubbles were observed.…”

Section: Discussionmentioning

confidence: 99%

Manufacture and acoustical characterisation of a high-frequency contrast agent for targeting applications

Moran

Ross

Cunningham

et al. 2006

Ultrasound in Medicine & Biology

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Section: Discussionmentioning

confidence: 99%

Manufacture and acoustical characterisation of a high-frequency contrast agent for targeting applications

Moran

Ross

Cunningham

et al. 2006

Ultrasound in Medicine & Biology

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“…This method involves using high intensity ultrasound to produce a suspension of gas microbubbles in a liquid containing a suitable surfactant or polymer solution which will adsorb on the surfaces of the microbubbles to form a stabilising coating [7,44,47,50]. In addition, the high temperatures and pressures generated by inertial cavitation in the liquid may result in chemical modification of the coating material that further enhances stability, although this depends upon the individual surfactant [48].…”

Section: Sonicationmentioning

confidence: 99%

Novel preparation techniques for controlling microbubble uniformity: a comparison

Stride

Edirisinghe

2009

Med Biol Eng Comput

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In recent years, there has been increasing interest in the use of coated microbubbles as vehicles for ultrasound mediated targeted drug delivery. This application requires a high degree of control over the size and uniformity of microbubbles, in order to ensure accurate dosing of a given drug and to maximise delivery efficiency. Similarly, as more advanced imaging techniques are developed which exploit the complex nonlinear features of the microbubble signal and/or enable quantification of tissue perfusion, the ability to predetermine the acoustic response of a microbubble suspension is becoming increasingly important. Consequently, a number of new preparation technologies have been developed to meet the demand for improved control over microbubble characteristics. The aim of the work described in this paper was to compare a conventional microbubble preparation technique, sonication, with two more recent methods: coaxial electrohydrodynamic atomisation and microfluidic (T-junction) processing, in terms of their ability to produce bubbles which are sufficiently small and stable for in vivo use, microbubble uniformity, relative production rates and other practical and economic considerations.

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“…At the same time, the dual-modality contrast agents for PA and US imaging have been investigated to improve the sensitivity and specificity. contrast agents [140,141]. due to the frequencies (on the order of MHz) of clinical US imaging systems, the sizes of these bubbles are on the order of micrometers.…”

Section: Dual-modality Photoacoustic and Ultrasound Contrast Agentsmentioning

confidence: 99%

Photoacoustic and Ultrasound Imaging with Nanosized Contrast Agents

Jeon

Kim

2014

Nanotechnology for Biomedical Imaging and Diagnostics

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Preparation, characterization and in vivo observation of phospholipid-based gas-filled microbubbles containing hirudin

Cited by 41 publications

References 24 publications

Manufacture and acoustical characterisation of a high-frequency contrast agent for targeting applications

Manufacture and acoustical characterisation of a high-frequency contrast agent for targeting applications

Novel preparation techniques for controlling microbubble uniformity: a comparison

Photoacoustic and Ultrasound Imaging with Nanosized Contrast Agents

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