Preparation, Characterization and Ex vivo Permeability Study of Transdermal Apixaban O/W Nanoemulsion Based Gel

Abdulbaqi, Mustafa R.; Rajab, Nawal A.

doi:10.31351/vol29iss2pp214-222

Cited by 11 publications

(10 citation statements)

References 17 publications

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“…The TEM images were taken to visualize the shape and vesicle size for the selected dispersion (F25) in which results showed nano-sized vesicles with spherical or deformed shapes at different magnification power, as shown in Figure . 8. These results agree with the results obtained from zeta sizer measurements (24) .…”

Section: Visualization Of Onds Loaded Invasomes Vesicles By Temsupporting

confidence: 92%

“…The selected best ONDS loaded invasomes dispersion was visualized for shape and vesicle size using TEM (CM 120, Philips, USA) with an accelerating voltage of 100 kV which was done by placing a sample on a carbon-coated copper grid. The sample was stained with 1.5% phosphotungstic acid for identification purposes and then visualized (24) .…”

Section: Visualization Of Invasome Vesicles By Transmission Electron ...mentioning

confidence: 99%

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Preparation, In-vitro, and Ex-vivo Evaluation of Ondansetron Loaded Invasomes for Transdermal Delivery

Salih,

Al-Akkam

2023

IJPS

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Invasomes are newly developed types of nanovesicles. A vesicular drug delivery system is considered one of the approaches for transdermal delivery to enhance permeation and improve drug bioavailability. Ondansetron is a serotonin receptor antagonist used for treating vomiting associated with different clinical cases. The study aimed to prepare invasomal dispersions for improving permeation of ondansetron across the skin with a controlled release pattern. Twenty-seven formulas of ondansetron-loaded invasomes were prepared by a modified mechanical dispersion method. These formulas were optimized by studying the effect of variables on entrapment efficiency. Vesicle size, polydispersity, zeta potential, in-vitro release and ex-vivo permeation studies were done for the optimized formulas. The selected formula was )F25( had )88.24%±0.04 (entrapment, (317.7 nm) vesicle size, (0.29) polydispersity, and (-31.5mV) zeta potential. In-vitro release study showed That (F25) had 75% release after (12) hrs., and dissolution followed the Korsmeyer-Peppas model with anomalous diffusion. Ex-vivo permeation study showed steady-state flux was 340.2 µg/cm2.hr with no lag time using rat skin tissue. A transmission electron microscope was done to visualize the selected formula. Invasomes are considered promising drug delivery systems for transdermal delivery of ondansetron, ensuring efficient permeation with a sustained release pattern.

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Section: Visualization Of Onds Loaded Invasomes Vesicles By Temsupporting

confidence: 92%

Section: Visualization Of Invasome Vesicles By Transmission Electron ...mentioning

confidence: 99%

Preparation, In-vitro, and Ex-vivo Evaluation of Ondansetron Loaded Invasomes for Transdermal Delivery

Salih,

Al-Akkam

2023

IJPS

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“…Phase separation was observed in (F1 and F2), which use HPMC K4M as a gelling agent after 2 months of storage at (25 ± 3 °C), while no phase separation in (F3 and F4) was reported, which might be related to the stability issues of the cellulose derivative polymer, that was more prone to be affected by storage factors. Carbopol 934P showed a more stable structure with time, favoring its use more frequently than cellulose derivative polymers [13]. All formulas were washable with water, neutral, and compatible with skin pH (pHskin = 7.2 -7.4).…”

Section: Formula's Physical Appearancementioning

confidence: 99%

Preparation, Evaluation, and Histopathological Studies of Ondansetron-Loaded Invasomes Transdermal Gel

SALIH,

MUHAMMED

2024

jrp

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Ondansetron is a serotonin receptor antagonist for treating nausea and vomiting. Its multiple daily doses and extensive first-pass metabolism faced parenteral and oral administration challenges. The transdermal route enhances its bioavailability as it bypasses the first-pass effect. Invasome vesicles improve the skin permeation of ondansetron via its unique components, lecithin, limonene, and ethanol, which are considered efficient permeation enhancers. The current study intends to develop a gel containing ondansetron as invasomes vesicles with appropriate texture and efficient skin penetration. Two gelling agents, hydroxypropyl methylcellulose K4M and carbopol 934P, were used at two concentrations (0.5 and 1%, w/w). Formulas were evaluated regarding pH, content uniformity, viscosity, spreadability, and ex vivo permeation. The selected formula (F3), which contained ondansetron (5%, w/w) and used carbopol 934P at (0.5%, w/w), was homogeneous, with proper viscosity (21,500 ± 390 mPa.s) at rest and enough spreadability (3.4 ± 0.45 cm). The ex vivo permeation showed permeation flux (Jss) was (280.4 ± 3.5 g/cm2.h) with a shorter lag time (0.5 ± 0.1 h). Characterization studies revealed nanosized vesicles (Dav. = 202.9 ± 0.5 nm) as spherical shapes dispersed within a gel matrix. In vivo, skin irritation and histopathology studies using male Wistar albino rats demonstrated that (F3) was biocompatible, with no irritation reported for six consecutive days. In conclusion, the invasomes gel of ondansetron utilizing carbopol (0.5%, w/w) was prepared for transdermal delivery, offering effective permeation and safe application. An invasomes-loaded gel is considered a novel formulation, giving an efficient and realistic therapeutic option for treating vomiting.

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“…The compatibility of RNB with another excipient in RNB-NLC was assessed using FTIR spectroscopy (Shimadzu, Japan) at the range 4000-400 cm -1 to check possible chemical interaction between their functional groups. 13 FTIR was performed for pure RNB, glyceryl monostearate, and the optimum RNB-NLC formula.…”

Section: Fourier Transform Infrared Spectroscopy (Ftir)mentioning

confidence: 99%

Preparation and Evaluation of Rizatriptan Benzoate Loaded Nanostructured Lipid Carrier Using Diff erent Surfactant/Co-Surfactant Systems

Rajab¹,

Jawad²

2023

IJDDT

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Migraine is the second most common neurological illness, aff ecting around one billion people each year; triptans are commonly used in the treatment; rizatriptan benzoate is a member of the triptan class, it’s available as a tablet dosage form. Unfortunately, it undergoes fi rst-pass eff ect after oral intake. The intranasal route of administration represents a solve to such a problem. Because it has a limited permeability, an eff ort has been made to circumvent this hurdle. Nanotechnology’s innovation has off ered a useful answer to several issues in the pharmaceutical fi eld in which it could improve drug permeability. The aim of the present work involved loading rizatriptan benzoate on a nanostructured lipid carrier as an attempt to resolve adversity affi liated with the intended drug. The high-speed homogenization technique prepares six formulas. The formulations’ particle size, polydispersity index, zeta potential, entrapment effi ciency, loading capacity, and in-vitro drug release were studied. Diff erential scanning calorimetry (DSC), Fourier transforms infrared spectroscopy (FTIR), and powder X-ray diff raction (PXRD) was investigated to exclude drug excipient incompatibility and to evaluate the crystallinity state of rizatriptan benzoate before and after formulation. Successful formulations were obtained with an acceptable nanostructured parameter In-vitro drug release profi le illustrates a biphasic pattern in which an immediate followed by a persistent phase over a 6 hours. release period, with an estimated percent of the medication being released with an anomalous release mechanism. The compatibility and crystallinity investigation revealed that rizatriptan benzoate was compatible with the other excipients used in the research, and the drug molecule was found to be in an amorphous state within the lipid matrix. In conclusion, nanostructured lipid carriers might be a potential delivery approach for improving intranasal administration of rizatriptan benzoate.

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Preparation, Characterization and Ex vivo Permeability Study of Transdermal Apixaban O/W Nanoemulsion Based Gel

Cited by 11 publications

References 17 publications

Preparation, In-vitro, and Ex-vivo Evaluation of Ondansetron Loaded Invasomes for Transdermal Delivery

Preparation, In-vitro, and Ex-vivo Evaluation of Ondansetron Loaded Invasomes for Transdermal Delivery

Preparation, Evaluation, and Histopathological Studies of Ondansetron-Loaded Invasomes Transdermal Gel

Preparation and Evaluation of Rizatriptan Benzoate Loaded Nanostructured Lipid Carrier Using Diff erent Surfactant/Co-Surfactant Systems

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