Preparation, Characterization, and Evaluation of Dipfluzine–Benzoic Acid Co-crystals with Improved Physicochemical Properties

Abstract

The co-crystal of dipfluzine-benzoic acid improved the physicochemical properties of dipfluzine, such as solubility and dissolution rate. Furthermore, the increased relative bioavailability of co-crystal indicated the potential use in further clinical study.

Raman and Terahertz Spectroscopic Investigation of Cocrystal Formation Involving Antibiotic Nitrofurantoin Drug and Coformer 4-aminobenzoic Acid

“…The absorption spectra of grinding cocrystal distinguish at frequencies 1.05 and 1.40 THz, with pretty broader bands comparing with that of physical mixture. It is well-known that the cocrystallization occurs as the result of intermolecular hydrogen bonding, nonionic or other nonconvalent interactions between two or more molecules of the different components [14][15][16]. So the experimental results indicate that the vibrational modes observed in these spectra are mostly intermolecular character between 4ABA and NF molecules during the cocrystal formation process.…”

“…Traditional techniques that could be employed include powder X-ray diffractormetry (PXRD) [5,[16][17][18]22], thermal analysis such as differential scanning calorimetry (DSC), and also solid-state nuclear magnetic resonance spectroscopy (ss-NMR) [19][20][21][22]. These established techniques are sometimes time consuming or lack in specific structural information about the crystalline and/or molecules, especially the effect from the intra-molecular and weak inter-molecular interactions.…”

Raman and Terahertz Spectroscopic Investigation of Cocrystal Formation Involving Antibiotic Nitrofurantoin Drug and Coformer 4-aminobenzoic Acid

“…Differences in crystal structures of cocrystals could be observed and evaluated by lots of research technologies. Traditional techniques that could be employed include powder X-ray diffractormetry (PXRD) [5,[18][19][20], thermal analysis(such as differential scanning calorimetry, DSC), and also solid-state nuclear magnetic resonance spectroscopy (ss-NMR) [20][21][22][23][24]. These established techniques are sometimes time-consuming or lack specific structural information about crystals and/or molecules-especially the effect from the intra-molecular and weak inter-molecular interactions.…”

Pharmaceutical solvates, hydrates and amorphous forms: A special emphasis on cocrystals

“…These spectroscopic techniques are generally considered as complementary techniques to X-ray based diffraction techniques. X-ray diffraction based methods provide more detailed structural information, whereas SSNMR provides information related to a local molecular environment, such as the number of symmetry independent molecules and their characteristic chemical shift values related to particular solid forms [186,187]. SSNMR analyzes the surrounding environments of molecules/atoms in their solid form and can be employed to study cocrystal polymorphism.…”