Preparation, Characterization, and Evaluation of Anti-Inflammatory Activity of Etoricoxib Loaded Soluplus® Nanocomposites

Abstract

Objective: The objective of this study was to prepare and characterize etoricoxib (ECB) loaded Soluplus® nanocomposites to improve its physicochemical properties. The effect of polymer and surfactant concentration on particle size, in vitro percentage dissolution efficiency and the anti-inflammatory activity of nanocomposites were also investigated.Methods: The nanocomposites were prepared by using a freeze-drying technique. The analytical evidence for the formulation of lyophilized nanocomposites in solid state were generated and confirmed by differential scanning calorimetry (DSC), fourier transformation infrared spectroscopy (FTIR), x-ray powder diffractometry (XPRD) and scanning electron microscopy (SEM). The in vitro drug release profile of nanocomposites was compared with pure ECB powder.Results: The nanocomposites of ECB were contained in a nano range with particle size and zeta potential of 63.5 nm and 46.5 mv, respectively. The solubility and dissolution of the nanocomposites were significantly (p<0.001) improved as compared to ECB alone, evidenced by decreased log P values (1.90±0.002) of the nanocomposites. The characterization studies revealed the formation of amorphous nanocomposites of ECB with existence of physical interactions between drug and polymer. The anti-inflammatory activity of nanocomposites evaluated by carrageenan-induced rat paw edema model demonstrated nonsignificant (p>0.05) increase in anti-inflammatory activity as compared to pure ECB.Conclusion: From the results, it could be concluded that the formation of ECB nanocomposites with Soluplus® could be an effective and alternative approach to modify the physicochemical properties of ECB.

Biodegradable Gg-cl-poly(NIPAm-co-AA)/-o-MWCNT based hydrogel for combined drug delivery system of metformin and sodium diclofenac: in vitro studies

“…37,38 The bands at 1579.73, 1497.90, 1263.38, 1048.27 and 663.59 cm −1 corresponding to the CC group of aromatic ring, C–N stretching and C–Cl group. 39 All of the bands found in the drug molecule as well as the newly formed functional groups C–O–C and hydrogen connected –NH may be seen in the FTIR spectra of a drug-loaded hydrogel. 40…”

Preparation and Enhancing Properties of pH‐Sensitive Hydrogel in Light of Gum Ghatti‐cl‐poly(acrylic acid)/ – o‐MWCNT for Sodium Diclofenac Drug Release

“…[ 38,39 ] The bands at 1512, 1465, 1280, 1081, and 670 cm −1 , correspond to the CC group of aromatic ring, CN stretching, and CCl groups. [ 40 ] All of the bands found in the drug molecule as well as the newly formed functional groups COC and hydrogen connected NH may be seen in the FTIR spectra of a drug‐loaded hydrogel. [ 41 ]…”

Emulsion Polymers of Carboxymethyl Cellulose and Methyl Methacrylate with Tetrabutylammonium Hydroxide Surfactant as Soil Stabilizer

“…A sharp peak observed at 1726 cm -1 was attributed to the C=O stretching vibration in the ester group of MMA [16], while the absorption band at 1445 cm -1 confirms the presence of carboxyl groups in CMC as salts [20]. A shoulder peak observed at 1481cm -1 was assigned to the C-N stretching in TBAOH surfactant [21].…”