Preparation, Characterization, and Controlled Release from Coprecipitates of Fluorescein and Magnesium Hydroxide

Fluorescent Magnesium Hydroxide Nanosheet Bandages with Tailored Properties for Biocompatible Antimicrobial Wound Dressings and pH Monitoring

“…Reports of fluorescent magnesium hydroxide are scarce in the literature. Early attempts to create fluorescent Mg­(OH) 2 relied on the absorption and adsorption of fluorescent dyes (i.e., fluorescein) to the particles . Although dye absorption was possible, its interaction was weak, and dye leaching was apparent.…”

“…Early attempts to create fluorescent Mg(OH) 2 relied on the absorption and adsorption of fluorescent dyes (i.e., fluorescein) to the particles. 22 Although dye absorption was possible, its interaction was weak, and dye leaching was apparent. Improvements to this approach were reported by Calderoń et al and involved the functionalization of Mg(OH) 2 with silicon precursors, which have a strong affinity for fluorescent dyes.…”

Sustained release of insulin from insoluble inhaled particles

“…Other examples include lipophilic drugs, e.g., pentamidine, which was retained in the lungs for 48 h [Debs et al, 1987], and coprecipitates with metal hydroxides (e.g., coprecipitate of fluorescein with magnesium hydroxide) [Hickey and Byron, 1986]. More recently, estradiol, a lipophilic compound, has been prepared as a large and porous aerosol and shown to induce in the rat sustained systemic delivery of the hormone for 5 days, vs. 1 day for nonporous particles of standard size (i.e., <5 µm) .…”