Preparation, Characterization and Biological Study of New Boron Compound and Schiff Base Derived From 2-Aminophenol with Their Cu (II) and Pt (IV) Complexes

Abstract

Two new ligands derived from 2-aminophenol have been prepared. The first ligand (boron compound) L 1 was prepared by refluxing one mole of sodium borohydride with two mole of 2-aminophenol in a mixture of methanol: acetone (2:1) .The second ligand (Schiff base) L 2 was prepared by refluxing equimolar from 4-bromoacetophenone and 2-aminophenol in methanol: acetone (2:1). Cu (II) and Pt (IV) complexes of ligands have been also prepared. The ligands and their metal complexes were characterized by elemental analysis, molar conductivity and spectral studies of FTIR, 1 H, 13 CNMR, thermal analysis, UV-VIS, as well as atomic absorption and magnetic susceptibility of metal complexes. All prepared compounds were tested as antibacterial agents against gram negative bacteria (E-coli)and gram positive bacteria (Staphylococcus aureus).

Synthesis, Characterization, Cyclic Voltammetry, and Biological Studies of Co(II), Ni(II), and Cu(II) Complexes of a Tridentate Schiff Base, 1-((E)-(2-Mercaptophenylimino) Methyl) Naphthalen-2-ol (H2L1)

“…However, the peak in the range 10-11 ppm corresponds to the possible enamine tautomerization proton. Moreover, the signal observed at 3.34 ppm, corresponding to two protons in Co(II) complex spectrum, is assigned to one water molecule of crystallization [38]. e above conclusion is in agreement with the IR analysis which confirmed that the ligand is tridentate and coordinates to the metal using the azomethine nitrogen, phenolic oxygen, and thiophenolic sulfur atoms.…”

“…A comparison of 1 H-NMR spectra of copper, cobalt, and nickel complexes with that of the free ligand displayed an upfield shift in the signal of azomethine proton which appeared at 8.09-8.36 ppm suggesting the coordination of azomethine nitrogen to the metal ions [37]. However, signals at 15.01 ppm and 3.35 ppm corresponding to a hydroxyl group and thiol group, respectively, in free ligand were found to be absent in both complexes, indicating the deprotonation of the hydroxyl group of naphthaldehyde moiety and thiol group of 2-aminothiophenol [38]. However, the peak in the range 10-11 ppm corresponds to the possible enamine tautomerization proton.…”

“…On the other hand, the azomethine proton (-HC�N-) appeared as a strong singlet at 9.78 ppm, confirming the formation of the Schiff base. All the aromatic protons were observed at 7.89-7.02 ppm [38].…”