Preparation, Characterization and Antioxidant Determination of Coumarin Substituted Heterocyclic Compound

Abd-Almonuim, Afnan E.; Mohammed, Shaimaa M.; Al-Khalifa, Ihab I.

doi:10.5958/0974-4150.2020.00006.1

Cited by 4 publications

(1 citation statement)

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“…A coumarin–benzothiazole hybrid was synthesized and tested for antioxidant action with DPPH (0.2 mM, DPPH, 20 min cultivation, 28 °C) [ 35 ]. Results were compared to ascorbic acid.…”

Section: Antioxidant Properties Of Molecular Coumarinsmentioning

confidence: 99%

Antioxidant Activity of Coumarins and Their Metal Complexes

Todorov

Saso²,

Kostova

2023

Pharmaceuticals

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Ubiquitously present in plant life, coumarins, as a class of phenolic compounds, have multiple applications—in everyday life, in organic synthesis, in medicine and many others. Coumarins are well known for their broad spectrum of physiological effects. The specific structure of the coumarin scaffold involves a conjugated system with excellent charge and electron transport properties. The antioxidant activity of natural coumarins has been a subject of intense study for at least two decades. Significant research into the antioxidant behavior of natural/semi-synthetic coumarins and their complexes has been carried out and published in scientific literature. The authors of this review have noted that, during the past five years, research efforts seem to have been focused on the synthesis and examination of synthetic coumarin derivatives with the aim to produce potential drugs with enhanced, modified or entirely novel effects. As many pathologies are associated with oxidative stress, coumarin-based compounds could be excellent candidates for novel medicinal molecules. The present review aims to inform the reader on some prominent results from investigations into the antioxidant properties of novel coumarin compounds over the past five years.

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“…A coumarin–benzothiazole hybrid was synthesized and tested for antioxidant action with DPPH (0.2 mM, DPPH, 20 min cultivation, 28 °C) [ 35 ]. Results were compared to ascorbic acid.…”

Section: Antioxidant Properties Of Molecular Coumarinsmentioning

confidence: 99%

Antioxidant Activity of Coumarins and Their Metal Complexes

Todorov

Saso²,

Kostova

2023

Pharmaceuticals

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Design, Synthesis and Antitubercular Study of Novel Pyrazoline Moiety as Mycobacterium Tuberculosis shikimate kinase inhibitor

Deepika.

Maheshwari

Kumar

et al. 2022

RJPT

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A series of pyrazoline comprising coumarin moiety was docked against Mycobacterium tuberculosis shikimate kinase which is an essential target for novel anti tubercular drug design. When the designed pyrazoline containing coumarin derivatives were docked with the receptor (1U8A), the docking scores obtained were greater than the natural ligand and the standards of some derivatives. A number of substituted chalcones were synthesized from thiophene-2-carboxaldehyde by condensing with various substituted acetophenones in presence of sodium hydroxide as a base. Pyrazoline derivatives were prepared by the condensation of chalcones with coumarin carbohydrazide in the presence of ethanol as the catalyst. The structures of the final synthesized compounds were confirmed by spectral analysis. Analogue 3a showed profound antitubercular activity against the organism at lower concentration.

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An In vitro Evaluation of Potential Free Radical Scavenging Antioxidant activity of selected Novel Synthetic Flavones

Bhixavatimath

Naikawadi

Maniyar

et al. 2022

RJPT

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Background: The study of free radicals nowadays have become more attention as these are evoked continuously due to hazardous environmental conditions and food habits. Endogenously free radicals are introduced in our body due to exposure to different physiochemical conditions or some pathological states by various mechanisms. Oxidative stress occurs due to exposure of excess free radicals to body. Antioxidants act as a major defence against the free radical-mediated injury by scavenging them. Majority of the flavonoids found in plant products are known as antioxidants as they selectively scavenge the free radicals. Methods: Synthetic flavones (VMF41, VMF 43, VMF 45 and VMF 46) having different side chains on the: 3-hydroxy-2- (5-methyl, 7-methyl, 6-methyl, and 7--methoxy) 2- thiophen-4H-chromen-4-one structure were examined for free radical scavenging potential over nitric oxide, hydroxyl, and superoxide anion radicals by using appropriate in-vitro assay methods. Results and Discussion: Overall, with few exceptions, all the synthetic flavonoids (SFs) exhibited moderate free radical scavenging activity as compared to the standard drug. The test samples in the study showed dose dependant activity of scavenging activity. In nitric oxide radial scavenging activity, test flavonoids VMF 45 and VMF 46 exhibited significant scavenging activity at 50- 100µg/ml concentrations. The SFs VMF 43 and VMF 46 showed a good scavenging activity for hydroxyl, nitric oxide radicals and compounds VMF41, and VMF 43 showed significant scavenging activity at 50 µg/ml to 100µg/ml concentrations for superoxide radicals. However all the SFs at 10µg/ml concentration showed the low or poor radical scavenging activity. Conclusion: It is clear that these synthetic flavonoids (SFs) can be considered as potential antioxidant agents, however needs to be further tested at in vivo experiment to consider them as a lead antioxidant drug candidates.

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Preparation, Characterization and Antioxidant Determination of Coumarin Substituted Heterocyclic Compound

Cited by 4 publications

References 0 publications

Antioxidant Activity of Coumarins and Their Metal Complexes

Antioxidant Activity of Coumarins and Their Metal Complexes

Design, Synthesis and Antitubercular Study of Novel Pyrazoline Moiety as Mycobacterium Tuberculosis shikimate kinase inhibitor

An In vitro Evaluation of Potential Free Radical Scavenging Antioxidant activity of selected Novel Synthetic Flavones

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