Preparation, characterization and antioxidant activities of acetylated polysaccharides from Cyclocarya paliurus leaves

Xie, Jianhua; Zhang, Fan; Wang, Zhijun; Shen, Mingyue; Nie, Shaoping; Xie, Mingyong

doi:10.1016/j.carbpol.2015.07.031

Cited by 110 publications

(43 citation statements)

References 29 publications

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“…A DEAE‐Sephadex A‐25 column (2.4 × 60 cm 2 ) was also used for separation . The refined CPPSs were repeatedly washed sequentially with anhydrous ethanol, acetone, and diethy ether after extraction, and then intensively dialyzed (14 kDa) against distilled water for 2 days to remove low‐molecular‐weight compounds . In addition, the H 2 O 2 solution and activated carbon are suggested for decolorization of the crude CPPSs.…”

Section: Extraction Methodsmentioning

confidence: 99%

“…The molecular weights of acetylated derivatives were approximately 1050–1090 kDa and mainly composed of Ara, Gal, Glc, Man, and GalA derivatives. Ac‐CP1, with a relatively low degree of substitution (DS = 0.13 ± 0.01), exhibited excellent antioxidant activity in a DPPH radical assay (95.21 ± 0.89%) and also had strong chelating activity on a β‐carotene–linoleic acid assay (34.64 ± 2.07%) at 0.5 mg/mL . Additionally, acetylated CPPS (DS = 0.681) had higher antioxidant activity .…”

Section: Hypoglycemic Effectsmentioning

confidence: 99%

“…Today, many studies indicate that C. paliurus leaves, seeds, and bark possess health benefits, such as antihypertensive activity, easing mental fatigue, and lifting antioxidant activity . These beneficial effects were largely due to its bioactive components.…”

Section: Introductionmentioning

confidence: 99%

“…[5][6][7] Today, many studies indicate that C. paliurus leaves, seeds, and bark possess health benefits, such as antihypertensive activity, easing mental fatigue, and lifting antioxidant activity. [8][9][10][11] These beneficial effects were largely due to its bioactive components. The chemical studies showed that C. paliurus contains extensive bioactive components, including polysaccharides, flavonoids, triterpenoids, amino acids, sterides, organic acids, mineral elements, and alkaloids, and these components contribute to its versatile effects, including antihyperglycemia, antihyperlipidemia, antihypertension, antioxidant, antitumor, and antimicrobial activities.…”

Section: Introductionmentioning

confidence: 99%

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Isolation, structure, and bioactivities of polysaccharides from Cyclocarya paliurus (Batal.) Iljinskaja

Xie

et al. 2017

Annals of the New York Academy of Sciences

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Cyclocarya paliurus (Batal.) Iljinskaja, a well-known edible and medicinal plant, has been widely used in China as a traditional medicine for treating hypertension and diabetes. C. paliurus possesses various bioactivities, such as antihyperglycemic, antihyperlipidemic, antihypertensive, anticancer, antifatigue, antioxidation, antimicrobial, colon health-promoting, and immunological activities. Polysaccharides, as natural macromolecules with various biological activities, are considered to be the main effective components in C. paliurus. Here, we summarize studies of polysaccharides from C. paliurus over the past 20 years, including extraction and purification processes, structure, and bioactivities.

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Section: Extraction Methodsmentioning

confidence: 99%

Section: Hypoglycemic Effectsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Isolation, structure, and bioactivities of polysaccharides from Cyclocarya paliurus (Batal.) Iljinskaja

Xie

et al. 2017

Annals of the New York Academy of Sciences

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“…The bioactivities of original polysaccharides could be improved by chemical modifications, such as sulfation, carboxymethylation, and acetylation (Lu, Mo, Guo, & Zhang, 2012;Xu et al, 2009;Yuan et al, 2005). Acetylated polysaccharides from Cyclocarya paliurus leaves with relatively low degree of substitution (DS) (0.13 ± 0.01) exhibited excellent antioxidant activity than the native polysaccharides (Xie et al, 2015). Carboxymethylation of polysaccharides from Tremella fuciformis could effectively enhance their antioxidant and moisture-preserving activities (Wang, Zhang, & Zhao, 2015).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and Antiproliferative Activities of Modified Polysaccharides Originally Isolated from Morchella Angusticepes Peck

Tang

Chen

et al. 2019

Journal of Food Science

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Polysaccharides extracted from Morchella angusticepes Peck (PMEP) were chemically modified to obtain sulfated, carboxymethylated, and acetyled derivatives. Results showed that the acetyled derivatives with the degree of substitution (0.40 ± 0.07) exerted higher antioxidant ability than native polysaccharides, demonstrating inhibitory effects on growth of human hepatoma cells (EC50 = 0.710 ± 0.002 mg/mL) and human colon cancer cells (EC50 = 1.229 ± 0.008 mg/mL). It indicated that the acetylation was a favorable way to enhance the bioactivities of PMEP. Practical Application Polysaccharides extracted from Morchella angusticepes Peck (PMEP) have many health‐promoting properties. Chemical modifications could improve the bioactivities of polysaccharides. We demonstrated that acetylation enhanced the cellular antioxidant and antiproliferative activities of PMEP. The results support further research that explores clinical utility, and may justify ex vivo and in vivo designs toward that end.

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Preparation, characterization and antioxidant activity of acetylated garlic polysaccharide, and garlic polysaccharide‐Zn (II) complex

Chen

Huang

2021

J of Applied Polymer Sci

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Garlic polysaccharide (PS) was extracted from garlic by hot‐water extraction. Acetylated garlic polysaccharide (AcPS) and garlic polysaccharide‐zinc complex (ZnPS) were synthesized. The results of Fourier transform infrared spectroscopy and nuclear magnetic resonance spectroscopy analysis showed that the modifications were successful. The antioxidant activities of PS, AcPS, and ZnPS were further investigated in vitro, including scavenging superoxide anion and hydroxyl radicals, antilipid peroxidation capacity, and reducing power. The results showed that the scavenging abilities of AcPS and ZnPS on hydroxyl radical (The IC50 of PS, AcPS, and ZnPS were 2.86, 1.62 and, 1.49 mg/ml, respectively,) and superoxide anion radical (The scavenging rate of PS, AcPS, and ZnPS were 1.5% and 1.8%, and 2.3%, respectively, when concentration was at 1.0 mg/ml.) were stronger than that of PS, and the inhibitory effect of AcPS on lipid peroxidation was significantly stronger than that of PS (The IC50 of PS and AcPS were 1.05 and 0.53 mg/ml, respectively.). It indicated that the acetylation was a favorable way to enhance the antioxidant activity of garlic PS; ZnPS complex could be applied as potential candidate for antioxidant and Zn supplement.

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Preparation, characterization and antioxidant activities of acetylated polysaccharides from Cyclocarya paliurus leaves

Cited by 110 publications

References 29 publications

Isolation, structure, and bioactivities of polysaccharides from Cyclocarya paliurus (Batal.) Iljinskaja

Isolation, structure, and bioactivities of polysaccharides from Cyclocarya paliurus (Batal.) Iljinskaja

Antioxidant and Antiproliferative Activities of Modified Polysaccharides Originally Isolated from Morchella Angusticepes Peck

Preparation, characterization and antioxidant activity of acetylated garlic polysaccharide, and garlic polysaccharide‐Zn (II) complex

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