Preparation, characterization and antimalarial activity of dihydroartemisinin / β-cyclodextrin spray-dried powder

Pongsamart, Kasama; Limwikrant, Waree; Ruktanonchai, Uracha; Charoenthai, Nattawut; Puttipipatkhachorn, Satit

doi:10.1016/j.jddst.2022.103434

Cited by 1 publication

(3 citation statements)

References 41 publications

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“…A protozoan parasite from the genus Plasmodium induces malaria. This parasite is carried by female Anopheles mosquitoes causing malaria diseases to humans due to its biting 2 . In 2021, 247 million malaria cases occurred globally.…”

Section: Introductionmentioning

confidence: 99%

“…DHA gives high plasma concentration and is easy to synthesize. Thus, it is preferred as a malaria drug 2,9 . Extraction and isolation of artemisinin and its derivatives have been conducted by various methods 10–12 .…”

Section: Introductionmentioning

confidence: 99%

“…Thus, it is preferred as a malaria drug. 2,9 Extraction and isolation of artemisinin and its derivatives have been conducted by various methods. [10][11][12] A conventional extraction method of A. annua is conducted by liquid extraction using organic solvent such as hexane and petroleum ether.…”

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confidence: 99%

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Core–shell magnetic‐modified molecular imprinted polymer (Fe₃O₄@SiO₂@MIP) for dihydroartemisinin recognition and separation

Fauzia¹,

Andreas²,

Muzdalifah³

et al. 2023

Polymers for Advanced Techs

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Dihydroartemisinin (DHA) is an artemisinin derivative compounds that employs as malaria drug. Extraction and purification artemisinin derivatives by liquid extraction utilize organic solvent and results in mixtures of compounds requiring further purification process. In this study, core-shell magnetic molecular imprinted polymer (Fe 3 O 4 @SiO 2 @MIP) has been synthesized for DHA isolation. Methacrylic acid (MAA) and ethylene glycol dimethacrylate (EGDMA) were employed as monomer and cross-linker, respectively. Fe 3 O 4 was modified by tetraethyl orthosilicate (TEOS) to enhance stability and prevent aggregation. Nonimprinted polymer (Fe 3 O 4 @SiO 2 @NIP) was also prepared as a comparison. The Fourier transform infrared (FTIR) represented O O stretching of O O C bond (1,2,4-trioxane ring) at 825 cm À1 denoting that DHA has been successfully attached to MIP. Meanwhile, the morphology of Fe 3 O 4 @SiO 2 @MIP and Fe 3 O 4 @SiO 2 @NIP revealed uniform spherical-like form particle due to core-shell magnetic modification. The Brunaeur-Emmett-Teller (BET) revealed S BET of Fe 3 O 4 @SiO 2 @MIP and Fe 3 O 4 @SiO 2 @-NIP was 70.16 and 19.56 m 2 g À1 , respectively. The prepared materials owned a superparamagentic behavior as indicated by narrow loop and low remanence and coercivity.The binding study indicated that Fe 3 O 4 @SiO 2 @MIP and Fe 3 O 4 @SiO 2 @NIP were achieved optimum condition at pH 4, contact time 90 min and initial concentration 8 mg L À1 with adsorption capacity (q exp ) 1.026 mg g À1 for Fe 3 O 4 @SiO 2 @MIP and 0.806 for Fe 3 O 4 @SiO 2 @NIP. The selectivity of Fe 3 O 4 @SiO 2 @MIP was more than 60% in all over the ratio. The prepared MIP exhibited good selectivity toward DHA with imprinting factor (IF) 2.14 and selectivity coefficient (α) 3.43. The percent adsorption of Fe 3 O 4 @-SiO 2 @MIP did not changed after three times adsorption-desorption cycles. The result exhibited that Fe 3 O 4 @SiO 2 @MIP could effectively be used for DHA separation.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Core–shell magnetic‐modified molecular imprinted polymer (Fe₃O₄@SiO₂@MIP) for dihydroartemisinin recognition and separation

Fauzia¹,

Andreas²,

Muzdalifah³

et al. 2023

Polymers for Advanced Techs

View full text Add to dashboard Cite

show abstract

Preparation, characterization and antimalarial activity of dihydroartemisinin / β-cyclodextrin spray-dried powder

Cited by 1 publication

References 41 publications

Core–shell magnetic‐modified molecular imprinted polymer (Fe₃O₄@SiO₂@MIP) for dihydroartemisinin recognition and separation

Core–shell magnetic‐modified molecular imprinted polymer (Fe₃O₄@SiO₂@MIP) for dihydroartemisinin recognition and separation

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Preparation, characterization and antimalarial activity of dihydroartemisinin / β-cyclodextrin spray-dried powder

Cited by 1 publication

References 41 publications

Core–shell magnetic‐modified molecular imprinted polymer (Fe3O4@SiO2@MIP) for dihydroartemisinin recognition and separation

Core–shell magnetic‐modified molecular imprinted polymer (Fe3O4@SiO2@MIP) for dihydroartemisinin recognition and separation

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Product

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Core–shell magnetic‐modified molecular imprinted polymer (Fe₃O₄@SiO₂@MIP) for dihydroartemisinin recognition and separation

Core–shell magnetic‐modified molecular imprinted polymer (Fe₃O₄@SiO₂@MIP) for dihydroartemisinin recognition and separation