Preparation, Characteristics, and Advantages of Plant Protein-Based Bioactive Molecule Delivery Systems

Guan, Tong-Wei; Zhang, Zhiheng; Li, Xiaojing; Cui, Shaoning; McClements, David Julian; Wu, Xiaotian; Chen, Long; Long, Jie; Jiao, Aiquan; Qiu, Chao; Jin, Zhengyu

doi:10.3390/foods11111562

Cited by 19 publications

(12 citation statements)

References 103 publications

(75 reference statements)

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“…Different packaging materials have different effects on the physical and chemical properties of the carrier. Some studies have found that protein and chitosan are more popular as materials for carrier preparation, and extensive studies have reported their favorable effects on increasing intestinal absorption and the bioavailability of plant polyphenols [ 14 ]. The encapsulation mechanisms of polyphenols by nanocarriers are diverse, including ionic gel, eutectic, condensation, encapsulation, emulsification, freeze-drying, and yeast encapsulation.…”

Section: Common Bio-based Polymer Nano-delivery Of Polyphenolic Compo...mentioning

confidence: 99%

“…Protein is a multifunctional bio-based polymer with rich nutritional value and various functional properties, including emulsification, amphiphilicity, gelation, and foaming properties. Its unique chemical structure and functionality allow it to be engineered into nanoparticles, nanogels, nanoemulsions, nanofilms, and nanofibers that can deliver both hydrophilic and hydrophobic polyphenolic compounds [ 14 ]. The unique structure and physiological activity of polysaccharides, as bio-based polymers with a wide range of origins, allow them to be used as raw materials for the preparation of various types of nanocarriers and for the delivery of polyphenolic compounds [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

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Polyphenols as Plant-Based Nutraceuticals: Health Effects, Encapsulation, Nano-Delivery, and Application

Zhang

Sang

et al. 2022

Foods

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Plant polyphenols have attracted considerable attention because of their key roles in preventing many diseases, including high blood sugar, high cholesterol, and cancer. A variety of functional foods have been designed and developed with plant polyphenols as the main active ingredients. Polyphenols mainly come from vegetables and fruits and can generally be divided according to their structure into flavonoids, astragalus, phenolic acids, and lignans. Polyphenols are a group of plant-derived functional food ingredients with different molecular structures and various biological activities including antioxidant, anti-inflammatory, and anticancer properties. However, many polyphenolic compounds have low oral bioavailability, which limits the application of polyphenols in nutraceuticals. Fortunately, green bio-based nanocarriers are well suited for encapsulating, protecting, and delivering polyphenols, thereby improving their bioavailability. In this paper, the health benefits of plant polyphenols in the prevention of various diseases are summarized, with a review of the research progress into bio-based nanocarriers for the improvement of the oral bioavailability of polyphenols. Polyphenols have great potential for application as key formulations in health and nutrition products. In the future, the development of food-grade delivery carriers for the encapsulation and delivery of polyphenolic compounds could well solve the limitations of poor water solubility and low bioavailability of polyphenols for practical applications.

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Section: Common Bio-based Polymer Nano-delivery Of Polyphenolic Compo...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Polyphenols as Plant-Based Nutraceuticals: Health Effects, Encapsulation, Nano-Delivery, and Application

Zhang

Sang

et al. 2022

Foods

Self Cite

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show abstract

“…Proteins represent excellent carriers of polyphenols due to their functional properties of emulsification, amphiphilicity, gelation, and foam formation. They can form nanoemulsions, nanogels, nanoparticles, nanofibers, and nanofilms, producing hydrophilic and hydrophobic polyphenolic compounds [ 136 ]. Likewise, polysaccharides, due to their structure and physiological activity, represent very suitable nanocarriers for encapsulating and administering polyphenols.…”

Section: Encapsulation Of Bioactive Compoundsmentioning

confidence: 99%

Encapsulation of Bioactive Compounds for Food and Agricultural Applications

et al. 2022

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This review presents an updated scenario of findings and evolutions of encapsulation of bioactive compounds for food and agricultural applications. Many polymers have been reported as encapsulated agents, such as sodium alginate, gum Arabic, chitosan, cellulose and carboxymethylcellulose, pectin, Shellac, xanthan gum, zein, pullulan, maltodextrin, whey protein, galactomannan, modified starch, polycaprolactone, and sodium caseinate. The main encapsulation methods investigated in the study include both physical and chemical ones, such as freeze-drying, spray-drying, extrusion, coacervation, complexation, and supercritical anti-solvent drying. Consequently, in the food area, bioactive peptides, vitamins, essential oils, caffeine, plant extracts, fatty acids, flavonoids, carotenoids, and terpenes are the main compounds encapsulated. In the agricultural area, essential oils, lipids, phytotoxins, medicines, vaccines, hemoglobin, and microbial metabolites are the main compounds encapsulated. Most scientific investigations have one or more objectives, such as to improve the stability of formulated systems, increase the release time, retain and protect active properties, reduce lipid oxidation, maintain organoleptic properties, and present bioactivities even in extreme thermal, radiation, and pH conditions. Considering the increasing worldwide interest for biomolecules in modern and sustainable agriculture, encapsulation can be efficient for the formulation of biofungicides, biopesticides, bioherbicides, and biofertilizers. With this review, it is inferred that the current scenario indicates evolutions in the production methods by increasing the scales and the techno-economic feasibilities. The Technology Readiness Level (TRL) for most of the encapsulation methods is going beyond TRL 6, in which the knowledge gathered allows for having a functional prototype or a representative model of the encapsulation technologies presented in this review.

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“…However, the bioaccessibility of protein is greatly challenged by harsh barriers in the upper gastrointestinal tract (GIT) (i.e., extreme gastric pH, intestinal protease, ionic strength, and long transit time). Colloidal delivery systems show great potential to encapsulate and protect protein cargoes during oral transmission [ 7 , 8 ]. These applications include hormones, enzymes, and probiotics [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Controlling the Interaction between Starchy Polyelectrolyte Layers for Adjusting Protein Release from Nanocapsules in a Simulated Gastrointestinal Tract

2022

Foods

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Orally delivered bioactive proteins face great challenges in the harsh environment of the upper gastrointestinal tract (GIT) in the field of functional foods based on bioactive proteins. Therefore, it is necessary to design carriers and delivery systems that have the potential to overcome the problem of lower bioaccessibility for protein cargoes. In this work, we present a starchy oral colon-targeting delivery system, capable of improving the release profile of the protein cargoes. The starchy oral colon-targeting delivery system was fabricated using layer-by-layer assembly of starchy polyelectrolytes (carboxymethyl anionic starch and spermine cationic starch) onto the surface of protein nanoparticles via electrostatic interaction. The dynamic change in the interaction between the starchy polyelectrolytes affected the shell aggregation structure and determined the release kinetics of nanocapsules in the GIT. Specifically, the stronger interactions between the starchy layers and the thicker and more compact shell layer kept the nanocapsule intact in the simulated gastric and intestinal fluids, better-protecting the protein from degradation by digestive fluids, thus avoiding the burst release effect in the SGF and SIF. However, the nanocapsule could quickly swell with the decreasing molecular interactions between starchy polyelectrolytes, increasing protein release (63.61%) in the simulated colonic fluid. Therefore, release behaviors of protein cargoes could be appropriately controlled by adjusting the number of deposited layers of pH-sensitive starchy polyelectrolytes on the nanocapsule. This could improve the bioaccessibility of oral targeted delivery of bioactive proteins to the colon.

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Preparation, Characteristics, and Advantages of Plant Protein-Based Bioactive Molecule Delivery Systems

Cited by 19 publications

References 103 publications

Polyphenols as Plant-Based Nutraceuticals: Health Effects, Encapsulation, Nano-Delivery, and Application

Polyphenols as Plant-Based Nutraceuticals: Health Effects, Encapsulation, Nano-Delivery, and Application

Encapsulation of Bioactive Compounds for Food and Agricultural Applications

Controlling the Interaction between Starchy Polyelectrolyte Layers for Adjusting Protein Release from Nanocapsules in a Simulated Gastrointestinal Tract

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