Preparation, Box-Behnken Statistical Optimization, and In Vitro Characterization of a Self-nanoemulsifying Drug Delivery System for the Oral Delivery of Budesonide as a Poorly Soluble Drug
Abstract:Introduction Although the delivery of therapeutic compounds through an oral route is the most convenient route of administration exhibiting high patient compliance (1), in some cases, there are several challenges for the development of an oral drug delivery system which exerts appropriate bioavailability, pharmacokinetic profile, and suitable therapeutic outcomes (2-4). Poor aqueous solubility and low dissolution rates are among the major problems that are associated with the preparation of an oral drug delive… Show more
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